Localization and targeting of voltage-dependent ion channels in mammalian central neurons

Helene Vacher, Durga P. Mohapatra, James S. Trimmer

Research output: Contribution to journalReview articlepeer-review

395 Scopus citations


The intrinsic electrical properties and the synaptic input-output relationships of neurons are governed by the action of voltagedependent ion channels. The localization of specific populations of ion channels with distinct functional properties at discrete sites in neurons dramatically impacts excitability and synaptic transmission. Molecular cloning studies have revealed a large family of genes encoding voltage-dependent ion channel principal and auxiliary subunits, most of which are expressed in mammalian central neurons. Much recent effort has focused on determining which of these subunits coassemble into native neuronal channel complexes, and the cellular and subcellular distributions of these complexes, as a crucial step in understanding the contribution of these channels to specific aspects of neuronal function. Here we review progress made on recent studies aimed to determine the cellular and subcellular distribution of specific ion channel subunits in mammalian brain neurons using in situ hybridization and immunohistochemistry. We also discuss the repertoire of ion channel subunits in specific neuronal compartments and implications for neuronal physiology. Finally, we discuss the emerging mechanisms for determining the discrete subcellular distributions observed for many neuronal ion channels.

Original languageEnglish
Pages (from-to)1407-1447
Number of pages41
JournalPhysiological reviews
Issue number4
StatePublished - Oct 2008


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