TY - JOUR
T1 - Local inner-ear drug delivery and pharmacokinetics
AU - Salt, Alec N.
AU - Plontke, Stefan K.R.
N1 - Funding Information:
This work was supported by NIH/NIDCD DC01368.
PY - 2005/10/1
Y1 - 2005/10/1
N2 - Several drugs that are applied directly to the inner ear are in widespread clinical use for the treatment of inner-ear disorders. Many new substances and drug delivery systems specific to the inner ear are under development and in some cases are being evaluated in animal experiments and in clinical studies. However, the pharmacokinetics of drugs in the inner ear is not well defined and the field is plagued by technical problems in obtaining pure samples of the inner-ear fluids for analysis. Nevertheless, a basic understanding of the mechanisms of drug dispersal in the inner ear has emerged, which facilitates the design and interpretation of future pharmacokinetic studies.
AB - Several drugs that are applied directly to the inner ear are in widespread clinical use for the treatment of inner-ear disorders. Many new substances and drug delivery systems specific to the inner ear are under development and in some cases are being evaluated in animal experiments and in clinical studies. However, the pharmacokinetics of drugs in the inner ear is not well defined and the field is plagued by technical problems in obtaining pure samples of the inner-ear fluids for analysis. Nevertheless, a basic understanding of the mechanisms of drug dispersal in the inner ear has emerged, which facilitates the design and interpretation of future pharmacokinetic studies.
UR - https://www.scopus.com/pages/publications/26244433867
U2 - 10.1016/S1359-6446(05)03574-9
DO - 10.1016/S1359-6446(05)03574-9
M3 - Review article
C2 - 16214674
AN - SCOPUS:26244433867
SN - 1359-6446
VL - 10
SP - 1299
EP - 1306
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 19
ER -