Local-global parcellation of the human cerebral cortex from intrinsic functional connectivity mri

Alexander Schaefer, Ru Kong, Evan M. Gordon, Timothy O. Laumann, Xi Nian Zuo, Avram J. Holmes, Simon B. Eickhoff, B. T.Thomas Yeo

Research output: Contribution to journalArticlepeer-review

603 Scopus citations

Abstract

A central goal in systems neuroscience is the parcellation of the cerebral cortex into discrete neurobiological "atoms". Restingstate functional magnetic resonance imaging (rs-fMRI) offers the possibility of in vivo human cortical parcellation. Almost all previous parcellations relied on 1 of 2 approaches. The local gradient approach detects abrupt transitions in functional connectivity patterns. These transitions potentially reflect cortical areal boundaries defined by histology or visuotopic fMRI. By contrast, the global similarity approach clusters similar functional connectivity patterns regardless of spatial proximity, resulting in parcels with homogeneous (similar) rs-fMRI signals. Here, we propose a gradient-weighted Markov RandomField (gwMRF) model integrating local gradient and global similarity approaches. Using task-fMRI and rs-fMRI across diverse acquisition protocols, we found gwMRF parcellations to be more homogeneous than 4 previously published parcellations. Furthermore, gwMRF parcellations agreed with the boundaries of certain cortical areas defined using histology and visuotopic fMRI. Some parcels captured subareal (somatotopic and visuotopic) features that likely reflect distinct computational units within known cortical areas. These results suggest that gwMRF parcellations reveal neurobiologically meaningful features of brain organization and are potentially useful for future applications requiring dimensionality reduction of voxel-wise fMRI data. Multiresolution parcellations generated from1489 participants are publicly available (https://github.com/ThomasYeoLab/CBIG/ tree/master/stable-projects/brain-parcellation/Schaefer2018-LocalGlobal).

Original languageEnglish
Pages (from-to)3095-3114
Number of pages20
JournalCerebral Cortex
Volume28
Issue number9
DOIs
StatePublished - 2018

Keywords

  • Brain parcellation
  • Brodmann areas
  • Cytoarchitecture
  • Resting-state functional connectivity
  • Retinotopy

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