TY - JOUR
T1 - Local functional connectivity alterations in schizophrenia, bipolar disorder, and major depressive disorder
AU - Wei, Yange
AU - Chang, Miao
AU - Womer, Fay Y.
AU - Zhou, Qian
AU - Yin, Zhiyang
AU - Wei, Shengnan
AU - Zhou, Yifang
AU - Jiang, Xiaowei
AU - Yao, Xudong
AU - Duan, Jia
AU - Xu, Ke
AU - Zuo, Xi Nian
AU - Tang, Yanqing
AU - Wang, Fei
N1 - Funding Information:
This study was supported by funding from the National Natural Science Foundation of China ( 81271499 and 81571311 to Yanqing Tang, 81725005 and 81571331 to Fei Wang), Liaoning Pandeng Scholar (to Fei Wang), National Key Research and Development Program ( 2016YFC0904300 to Fei Wang), National High Tech Development Plan (863) ( 2015AA020513 to Fei Wang), and National Key Research and Development Program ( 2016YFC1306900 to Yanqing Tang).
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/8/15
Y1 - 2018/8/15
N2 - Background: Local functional connectivity (FC) indicates local or short-distance functional interactions and may serve as a neuroimaging marker to investigate the human brain connectome. Local FC alterations suggest a disrupted balance in the local functionality of the whole brain network and are increasingly implicated in schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). Methods: We aim to examine the similarities and differences in the local FC across SZ, BD, and MDD. In total, 537 participants (SZ, 126; BD, 97; MDD, 126; and healthy controls, 188) completed resting-state functional magnetic resonance imaging at a single site. The local FC at resting state was calculated and compared across SZ, BD, and MDD. Results: The local FC increased across SZ, BD, and MDD within the bilateral orbital frontal cortex (OFC) and additional region in the left OFC extending to putamen and decreased in the primary visual, auditory, and motor cortices, right supplemental motor area, and bilateral thalami. There was a gradient in the extent of alterations such that SZ > BD > MDD. Limitations: This cross-sectional study cannot consider medications and other clinical variables. Conclusions: These findings indicate a disrupted balance between network integration and segregation in SZ, BD, and MDD, including over-integration via increased local FC in the OFC and diminished segregation of neural processing with the weakening of the local FC in the primary sensory cortices and thalamus. The shared local FC abnormalities across SZ, BD, and MDD may shed new light on the potential biological mechanisms underlying these disorders.
AB - Background: Local functional connectivity (FC) indicates local or short-distance functional interactions and may serve as a neuroimaging marker to investigate the human brain connectome. Local FC alterations suggest a disrupted balance in the local functionality of the whole brain network and are increasingly implicated in schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). Methods: We aim to examine the similarities and differences in the local FC across SZ, BD, and MDD. In total, 537 participants (SZ, 126; BD, 97; MDD, 126; and healthy controls, 188) completed resting-state functional magnetic resonance imaging at a single site. The local FC at resting state was calculated and compared across SZ, BD, and MDD. Results: The local FC increased across SZ, BD, and MDD within the bilateral orbital frontal cortex (OFC) and additional region in the left OFC extending to putamen and decreased in the primary visual, auditory, and motor cortices, right supplemental motor area, and bilateral thalami. There was a gradient in the extent of alterations such that SZ > BD > MDD. Limitations: This cross-sectional study cannot consider medications and other clinical variables. Conclusions: These findings indicate a disrupted balance between network integration and segregation in SZ, BD, and MDD, including over-integration via increased local FC in the OFC and diminished segregation of neural processing with the weakening of the local FC in the primary sensory cortices and thalamus. The shared local FC abnormalities across SZ, BD, and MDD may shed new light on the potential biological mechanisms underlying these disorders.
UR - http://www.scopus.com/inward/record.url?scp=85046681010&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2018.04.069
DO - 10.1016/j.jad.2018.04.069
M3 - Article
C2 - 29751242
AN - SCOPUS:85046681010
SN - 0165-0327
VL - 236
SP - 266
EP - 273
JO - Journal of affective disorders
JF - Journal of affective disorders
ER -