TY - JOUR
T1 - Local field potential spectral tuning in motor cortex during reaching
AU - Heldman, Dustin A.
AU - Wang, Wei
AU - Chan, Sherwin S.
AU - Moran, Daniel W.
N1 - Funding Information:
Manuscript received July 20, 2005; revised March 15, 2006; accepted March 24, 2006. This work was supported in part by The Whitaker Foundation and performed in a facility supported by the NCRR under Grant C06 RR015502. The authors are with the Department of Biomedical Engineering, Washington University, St. Louis, MO 63130 USA (e-mail: dmoran@wustl.edu). Digital Object Identifier 10.1109/TNSRE.2006.875549 Fig. 1. Virtual reality setup. (a) Subject sits in primate chair looking at image projected onto mirror from 3-D computer monitor. He cannot see his hand, but rather a spherical cursor that represents position of hand in space. (b) For center-out task, subject must hold at central target projected in front of him for short period of time (500–1000 ms). Peripheral target will randomly appear at one of eight corners of a virtual cube and subject will immediately make smooth reach toward peripheral target and hold for set period (500–1000 ms).
PY - 2006/6
Y1 - 2006/6
N2 - In this paper, intracortical local field potentials (LFPs) and single units were recorded from the motor cortices of monkeys (Macaca fascicularis) while they preformed a standard three-dimensional (3-D) center-out reaching task. During the center-out task, the subjects held their hands at the location of a central target and then reached to one of eight peripheral targets forming the corners of a virtual cube. The spectral amplitudes of the recorded LFPs were calculated, with the high-frequency LFP (HF-LFP) defined as the average spectral amplitude change from baseline from 60 to 200 Hz. A 3-D linear regression across the eight center-out targets revealed that approximately 6% of the beta LFPs (18-26 Hz) and 18% of the HF-LFPs were tuned for velocity (p-value <0.05), while 10% of the beta LFPs and 15% of the HF-LFPs were tuned for position. These results suggest that a multidegree-of-freedom brain-machine interface is possible using high-frequency LFP recordings in motor cortex.
AB - In this paper, intracortical local field potentials (LFPs) and single units were recorded from the motor cortices of monkeys (Macaca fascicularis) while they preformed a standard three-dimensional (3-D) center-out reaching task. During the center-out task, the subjects held their hands at the location of a central target and then reached to one of eight peripheral targets forming the corners of a virtual cube. The spectral amplitudes of the recorded LFPs were calculated, with the high-frequency LFP (HF-LFP) defined as the average spectral amplitude change from baseline from 60 to 200 Hz. A 3-D linear regression across the eight center-out targets revealed that approximately 6% of the beta LFPs (18-26 Hz) and 18% of the HF-LFPs were tuned for velocity (p-value <0.05), while 10% of the beta LFPs and 15% of the HF-LFPs were tuned for position. These results suggest that a multidegree-of-freedom brain-machine interface is possible using high-frequency LFP recordings in motor cortex.
KW - Brain-computer interface (BCI)
KW - Local field potential (LFP)
KW - Motor cortex
UR - http://www.scopus.com/inward/record.url?scp=33746459471&partnerID=8YFLogxK
U2 - 10.1109/TNSRE.2006.875549
DO - 10.1109/TNSRE.2006.875549
M3 - Article
C2 - 16792288
AN - SCOPUS:33746459471
SN - 1534-4320
VL - 14
SP - 180
EP - 183
JO - IEEE Transactions on Neural Systems and Rehabilitation Engineering
JF - IEEE Transactions on Neural Systems and Rehabilitation Engineering
IS - 2
M1 - 1642763
ER -