Local blood-brain barrier penetration following systemic contrast medium administration: A case report and an experimental study

R. Utz, S. E. Ekholm, L. Isaac, M. Sands, D. Fonte

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The present study was initiated by a severe complication in a patient with renal dysfunction who developed cortical blindness and weakness of her left extremities 30 hours following renal and abdominal angiography. To evaluate the impact of prolonged high serum concentrations of contrast medium (CM) this clinical situation was simulated in a laboratory model using sheep with elevated serum levels of contrast medium maintained for 48 hours. The experimental data did not support the theory that the prolonged exposure to high circulating levels of contrast medium (4 ml/kg body weight of meglumine diatrizoate 60%) is sufficient alone to cause penetration of the blood-brain barrier.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalActa Radiologica
Volume29
Issue number2
DOIs
StatePublished - Mar 1988
Externally publishedYes

Keywords

  • Blood-brain barrier
  • clinical observation
  • contrast media, neurotoxicity
  • experimental model

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