Local and long-distance organization of prefrontal cortex circuits in the marmoset brain

Akiya Watakabe, Henrik Skibbe, Ken Nakae, Hiroshi Abe, Noritaka Ichinohe, Muhammad Febrian Rachmadi, Jian Wang, Masafumi Takaji, Hiroaki Mizukami, Alexander Woodward, Rui Gong, Junichi Hata, David C. Van Essen, Hideyuki Okano, Shin Ishii, Tetsuo Yamamori

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The prefrontal cortex (PFC) has dramatically expanded in primates, but its organization and interactions with other brain regions are only partially understood. We performed high-resolution connectomic mapping of the marmoset PFC and found two contrasting corticocortical and corticostriatal projection patterns: “patchy” projections that formed many columns of submillimeter scale in nearby and distant regions and “diffuse” projections that spread widely across the cortex and striatum. Parcellation-free analyses revealed representations of PFC gradients in these projections’ local and global distribution patterns. We also demonstrated column-scale precision of reciprocal corticocortical connectivity, suggesting that PFC contains a mosaic of discrete columns. Diffuse projections showed considerable diversity in the laminar patterns of axonal spread. Altogether, these fine-grained analyses reveal important principles of local and long-distance PFC circuits in marmosets and provide insights into the functional organization of the primate brain.

Original languageEnglish
Pages (from-to)2258-2273.e10
JournalNeuron
Volume111
Issue number14
DOIs
StatePublished - Jul 19 2023

Keywords

  • AAV
  • STPT
  • anterograde tracer
  • association cortex
  • cortical column
  • non-human primate
  • nonnegative matrix factorization
  • serial two-photon tomography
  • topographic connectivity
  • tractography

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