TY - JOUR
T1 - Lobular carcinoma in situ and infiltrating ductal carcinoma
T2 - Frequent presence of DCIS as a precursor lesion
AU - Maluf, Horacio
AU - Koerner, Frederick
PY - 2001
Y1 - 2001
N2 - Infiltrating ductal carcinoma (IDC) occurs frequently in patients with lobular carcinoma in-situ (LCIS). LCIS is not thought to be the direct precursor of the invasive component. The authors analyzed 15 cases of coexisting LCIS and IDC and found ductal carcinoma in situ (DCIS) in 12. The DCIS and IDC were of similar grade and located in the same area. Selected cases stained with E-cadherin demonstrated a different immunophenotype for the lobular and ductal lesions. These results support the notion that DCIS is the direct precursor of IDC occurring in patients with LCIS.
AB - Infiltrating ductal carcinoma (IDC) occurs frequently in patients with lobular carcinoma in-situ (LCIS). LCIS is not thought to be the direct precursor of the invasive component. The authors analyzed 15 cases of coexisting LCIS and IDC and found ductal carcinoma in situ (DCIS) in 12. The DCIS and IDC were of similar grade and located in the same area. Selected cases stained with E-cadherin demonstrated a different immunophenotype for the lobular and ductal lesions. These results support the notion that DCIS is the direct precursor of IDC occurring in patients with LCIS.
KW - Ductal carcinoma in situ
KW - E-cadherin
KW - Infiltrating ductal carcinoma
KW - Lobular carcinoma in situ
KW - Tubular carcinoma
UR - http://www.scopus.com/inward/record.url?scp=0034930973&partnerID=8YFLogxK
U2 - 10.1177/106689690100900206
DO - 10.1177/106689690100900206
M3 - Article
C2 - 11484500
AN - SCOPUS:0034930973
SN - 1066-8969
VL - 9
SP - 127
EP - 131
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 2
ER -