Lobular carcinoma in situ and infiltrating ductal carcinoma: Frequent presence of DCIS as a precursor lesion

Horacio Maluf, Frederick Koerner

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Infiltrating ductal carcinoma (IDC) occurs frequently in patients with lobular carcinoma in-situ (LCIS). LCIS is not thought to be the direct precursor of the invasive component. The authors analyzed 15 cases of coexisting LCIS and IDC and found ductal carcinoma in situ (DCIS) in 12. The DCIS and IDC were of similar grade and located in the same area. Selected cases stained with E-cadherin demonstrated a different immunophenotype for the lobular and ductal lesions. These results support the notion that DCIS is the direct precursor of IDC occurring in patients with LCIS.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalInternational Journal of Surgical Pathology
Volume9
Issue number2
DOIs
StatePublished - Jan 1 2001

Keywords

  • Ductal carcinoma in situ
  • E-cadherin
  • Infiltrating ductal carcinoma
  • Lobular carcinoma in situ
  • Tubular carcinoma

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