Lobular capillary hemangioma (pyogenic granuloma) of the gastrointestinal tract: Clinicopathologic analysis of 34 cases

Adam L. Booth, Lysandra Voltaggio, Rebecca Waters, John Goldblum, Michael M. Feely, Diana Agostini-Vulaj, Maryam Pezhouh, Raul S. Gonzalez

Research output: Contribution to journalArticlepeer-review


Objectives: Lobular capillary hemangioma (LCH) rarely involves the gastrointestinal (GI) tract. This study describes clinicopathologic features of LCH in a cohort of GI cases. Methods: We defined lobular capillary hemangioma as "a proliferation of capillary-sized blood vessels arranged at least focally in a lobular configuration,"searched departmental archives for cases, and recorded clinicopathologic findings. Results: We identified 34 GI tract LCHs from 16 men and 10 women; 4 patients had multiple lesions. Mean age was 64 years. Cases arose in the esophagus (n = 7), stomach (n = 3), small bowel (n = 7), and colorectum (n = 17). Twelve patients had anemia or rectal bleeding. No patients had a known genetic syndrome. The lesions manifested as mucosal polyps, with median size of 1.3 cm. Microscopically, 20 lesions were ulcerated, and most involved the mucosa, with 9 extending into the submucosa. Vessel dilation was present in 27 patients, endothelial hobnailing in 13, hemorrhage in 13, and focal reactive stromal atypia in 2. Follow-up information was available for 10 patients, none of whom developed same-site recurrence. Six of the 26 cases (23%) were extradepartmental consultations, including 2 of the multifocal cases. Conclusions: Gastrointestinal tract LCHs often arise as colorectal polyps. They are typically small but can reach a few centimeters in size and can be multifocal.

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalAmerican journal of clinical pathology
Issue number4
StatePublished - Oct 1 2023


  • gastrointestinal tract
  • lobular capillary hemangioma
  • pyogenic granuloma


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