Lobectomia temporal anterior versus amigdalohipocampectomia seletiva para epilepsia de lobo temporal mesial

Fábio A. Nascimento; Luana Antunes Maranha Gatto; Carlos Silvado; Maria Joana Mäder-Joaquim; Marlus Sidney Moro; Joao Candido Araujo

doi:10.1590/0004-282X20150188

Lobectomia temporal anterior versus amigdalohipocampectomia seletiva para epilepsia de lobo temporal mesial

Translated title of the contribution: Anterior temporal lobectomy versus selective amygdalohippocampectomy in patients with mesial temporal lobe epilepsy

Fábio A. Nascimento, Luana Antunes Maranha Gatto, Carlos Silvado, Maria Joana Mäder-Joaquim, Marlus Sidney Moro, Joao Candido Araujo

Section of Adult Epilepsy

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Objective: To contribute our experience with surgical treatment of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH). Method: This is a retrospective observat ional study. The sample included patients with medically refractory mTLE due to unilateral mesial temporal sclerosis who underwent either ATL or SelAH, at Hospital de Clinicas – UFPR, from 2005 to 2012. We report seizure outcomes, using Engel classification, cognitive outcomes, using measurements of verbal and visuospatial memories, as well as operative complications. Result: Sixty-seven patients (33 ATL, 34 SelAH) were studied; median follow-up was 64 months. There was no statistically significant difference in seizure or neuropsychological outcomes, although verbal memory was more negatively affected in ATL operations on patients’ dominant hemispheres. Higher number of major complications was observed in the ATL group (p = 0.004). Conclusion: Seizure and neuropsychological outcomes did not differ. ATL appeared to be associated with higher risk of complications.

Translated title of the contribution	Anterior temporal lobectomy versus selective amygdalohippocampectomy in patients with mesial temporal lobe epilepsy
Original language	Portuguese (Brazil)
Pages (from-to)	35-43
Number of pages	9
Journal	Arquivos de Neuro-Psiquiatria
Volume	74
Issue number	1
DOIs	https://doi.org/10.1590/0004-282X20150188
State	Published - Jan 2016

Keywords

Amygdalo-hippocampal epilepsy
Anterior temporal lobectomy
Neuropsychological tests
Postoperative complications
Seizures
Temporal lobe epilepsy

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title = "Lobectomia temporal anterior versus amigdalohipocampectomia seletiva para epilepsia de lobo temporal mesial",

abstract = "Objective: To contribute our experience with surgical treatment of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH). Method: This is a retrospective observat ional study. The sample included patients with medically refractory mTLE due to unilateral mesial temporal sclerosis who underwent either ATL or SelAH, at Hospital de Clinicas – UFPR, from 2005 to 2012. We report seizure outcomes, using Engel classification, cognitive outcomes, using measurements of verbal and visuospatial memories, as well as operative complications. Result: Sixty-seven patients (33 ATL, 34 SelAH) were studied; median follow-up was 64 months. There was no statistically significant difference in seizure or neuropsychological outcomes, although verbal memory was more negatively affected in ATL operations on patients{\textquoteright} dominant hemispheres. Higher number of major complications was observed in the ATL group (p = 0.004). Conclusion: Seizure and neuropsychological outcomes did not differ. ATL appeared to be associated with higher risk of complications.",

keywords = "Amygdalo-hippocampal epilepsy, Anterior temporal lobectomy, Neuropsychological tests, Postoperative complications, Seizures, Temporal lobe epilepsy",

author = "Nascimento, {F{\'a}bio A.} and Gatto, {Luana Antunes Maranha} and Carlos Silvado and M{\"a}der-Joaquim, {Maria Joana} and Moro, {Marlus Sidney} and Araujo, {Joao Candido}",

year = "2016",

month = jan,

doi = "10.1590/0004-282X20150188",

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AU - Nascimento, Fábio A.

AU - Gatto, Luana Antunes Maranha

AU - Silvado, Carlos

AU - Mäder-Joaquim, Maria Joana

AU - Moro, Marlus Sidney

AU - Araujo, Joao Candido

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N2 - Objective: To contribute our experience with surgical treatment of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH). Method: This is a retrospective observat ional study. The sample included patients with medically refractory mTLE due to unilateral mesial temporal sclerosis who underwent either ATL or SelAH, at Hospital de Clinicas – UFPR, from 2005 to 2012. We report seizure outcomes, using Engel classification, cognitive outcomes, using measurements of verbal and visuospatial memories, as well as operative complications. Result: Sixty-seven patients (33 ATL, 34 SelAH) were studied; median follow-up was 64 months. There was no statistically significant difference in seizure or neuropsychological outcomes, although verbal memory was more negatively affected in ATL operations on patients’ dominant hemispheres. Higher number of major complications was observed in the ATL group (p = 0.004). Conclusion: Seizure and neuropsychological outcomes did not differ. ATL appeared to be associated with higher risk of complications.

AB - Objective: To contribute our experience with surgical treatment of patients with mesial temporal lobe epilepsy (mTLE) undergoing anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SelAH). Method: This is a retrospective observat ional study. The sample included patients with medically refractory mTLE due to unilateral mesial temporal sclerosis who underwent either ATL or SelAH, at Hospital de Clinicas – UFPR, from 2005 to 2012. We report seizure outcomes, using Engel classification, cognitive outcomes, using measurements of verbal and visuospatial memories, as well as operative complications. Result: Sixty-seven patients (33 ATL, 34 SelAH) were studied; median follow-up was 64 months. There was no statistically significant difference in seizure or neuropsychological outcomes, although verbal memory was more negatively affected in ATL operations on patients’ dominant hemispheres. Higher number of major complications was observed in the ATL group (p = 0.004). Conclusion: Seizure and neuropsychological outcomes did not differ. ATL appeared to be associated with higher risk of complications.

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Lobectomia temporal anterior versus amigdalohipocampectomia seletiva para epilepsia de lobo temporal mesial

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