Lmx1b is essential for the development of serotonergic neurons

Yu Qiang Ding, Ulrika Marklund, Wenlin Yuan, Jun Yin, Lauren Wegman, Johan Ericson, Evan Deneris, Randy L. Johnson, Zhou Feng Chen

Research output: Contribution to journalArticlepeer-review

212 Scopus citations

Abstract

The specification and differentiation of serotonergic (5-HT) neurons require both extrinsic signaling molecules and intrinsic transcription factors to work in concert or in cascade. Here we identify the genetic cascades that control the specification and differentiation of 5-HT neurons in mice. A major determinant in the cascades is an LIM homeodomain-containing gene, Lmx1b, which is required for the development of all 5-HT neurons in the central nervous system. Our results suggest that, during development of 5-HT neurons, Lmx1b is a critical intermediate factor that couples Nkx2-2-mediated early specification with Pet1-mediated terminal differentiation. Moreover, our data indicate that genetic cascades controlling the caudal and rostral 5-HT neurons are distinct, despite their shared components.

Original languageEnglish
Pages (from-to)933-938
Number of pages6
JournalNature neuroscience
Volume6
Issue number9
DOIs
StatePublished - Sep 1 2003

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