Liver transplant pathology: a timeline based approach and review

Kathleen Byrnes, Kiyoko Oshima

Research output: Contribution to journalReview article

Abstract

Liver transplantation is becoming more widely used for the treatment of numerous diseases. Liver pathology has an important role in both donor selection and guidance for treatment decisions to preserve allografts. Pathologists are increasingly requested to perform frozen section analysis of donor liver because suboptimal allografts need to be utilized because of the shortage of available donor livers. Post-transplant liver biopsies can seem overwhelming due to the wide differential diagnosis compared to that for non-allograft liver biopsies. When evaluating allograft liver biopsies, attention to the morphologic pattern and correlation with clinical findings is essential. This review provides a brief overview of the differential diagnoses encountered in allograft biopsies and a guide to diagnosis using histologic findings and the timeline after transplantation.

Original languageEnglish
Pages (from-to)508-513
Number of pages6
JournalDiagnostic Histopathology
Volume24
Issue number12
DOIs
StatePublished - Dec 2018

Keywords

  • allografts
  • donor
  • graft rejection
  • liver pathology
  • liver transplantation

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