Liver disease in polyglandular autoimmune disease type one: Clinicopathologic study of three patients and review of the literature

Neal S. Goldstein, Philip Rosenthal, Frank Sinatra, Louis P. Dehner

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We report the findings from liver biopsies of three patients with polyglandular autoimmune disease type 1. The livers in two patients had histologic features of chronic hepatitis that eventuated in bridging fibrosis and cirrhosis over a period of several years. Nonspecific lobular and portal tract inflammation was present in the liver biopsy of the third patient. Although these patients did not have liver-specific autoantibodies, the liver disease in polyglandular autoimmune disease type 1 possibly represents an expression of autoimmune hepatitis.

Original languageEnglish
Pages (from-to)625-636
Number of pages12
JournalPediatric Pathology and Laboratory Medicine
Volume16
Issue number4
DOIs
StatePublished - 1996

Keywords

  • autoimmune
  • hepatitis
  • liver
  • polyglandular autoimmune disease

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