Liver cirrhosis in Fontan patients does not affect 1-year post-heart transplant mortality or markers of liver function

Kathleen E. Simpson, Amir Esmaeeli, Geetika Khanna, Francis White, Yumirle Turnmelle, Pirooz Eghtesady, Umar Boston, Charles E. Canter

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Background Liver cirrhosis is recognized with long-term follow-up of patients after the Fontan procedure. The effect of liver cirrhosis on the use of heart transplant (HT) and on post-HT outcomes is unknown. Methods We reviewed Fontan patients evaluated for HT from 2004 to 2012 with hepatic computed tomography (CT) imaging, classified as normal, non-cirrhotic changes, or cirrhosis. The primary outcome was 1-year all-cause mortality, and the secondary outcome was differences in serial post-HT liver evaluation. Results CT imaging in 32 Fontan patients evaluated for HT revealed 20 (63%) with evidence of liver disease, including 13 (41%) with cirrhosis. Twenty underwent HT, including 5 non-cirrhotic and 7 cirrhosis patients. Characteristics at listing between normal or non-cirrhotic (n = 13) and cirrhosis (n = 7) groups were similar, except cirrhosis patients were older (median 17.6 vs 9.6 years, p = 0.002) and further from Fontan (median 180 vs 50 months, p < 0.05). Serial liver evaluation was similar, including aspartate aminotransferase, alanine aminotransferase, bilirubin, albumin, and tacrolimus dose at 1, 3, 6, 9, and 12 months. Overall patient survival was 80% at 1 year, with no difference between cirrhosis and non-cirrhosis patients (86% vs 77%, p = 0.681). Liver biopsies were performed in 7 patients before HT, and all specimens showed architectural changes with bridging fibrosis. Conclusions Most patients evaluated for HT had abnormal liver findings by CT, with cirrhosis in 41%. One-year mortality and serial liver evaluation were similar between groups after HT. Liver cirrhosis identified by CT imaging may not be an absolute contraindication to HT alone in this population.

Original languageEnglish
Pages (from-to)170-177
Number of pages8
JournalJournal of Heart and Lung Transplantation
Volume33
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • Fontan procedure
  • heart transplant
  • liver cirrhosis
  • liver transplant
  • pediatric cardiology

Fingerprint

Dive into the research topics of 'Liver cirrhosis in Fontan patients does not affect 1-year post-heart transplant mortality or markers of liver function'. Together they form a unique fingerprint.

Cite this