Live Neuron High-Content Screening Reveals Synaptotoxic Activity in Alzheimer Mouse Model Homogenates

Keyphrases

• Alzheimer's Disease Model 100%
• Synaptic Remodeling 100%
• High-content Screening 100%
• Brain Homogenate 66%
• Synaptic Puncta 66%
• Molecular Mechanism 33%
• Spontaneous Excitatory Postsynaptic Current (sEPSC) 33%
• Glutamate 33%
• Primary Neurons 33%
• Imaging Methods 33%
• Serial Imaging 33%
• Amyloid beta 33%
• Toxic Effects 33%
• Accurate Quantification 33%
• Size Exclusion Chromatography 33%
• Synaptogenesis 33%
• Therapeutic Use 33%
• Synaptic Plasticity 33%
• VAMP2 33%
• MTT Assay 33%
• Postsynaptic Density Protein 95 (PSD-95) 33%
• 96-well Plate 33%
• High Molecular Weight Fraction 33%
• Novel Assay 33%
• Protein Sample 33%
• High-content Imaging 33%
• 3xTg-AD Mice 33%
• Synaptic Toxicity 33%
• Low Molecular Weight Fraction 33%
• Immunodepletion 33%
• Automatic Image Analysis 33%

Neuroscience

• Alzheimer's Disease 100%
• Glutamic Acid 100%
• Beta Amyloid 100%
• MTT Assay 100%
• Synaptic Plasticity 100%
• Synaptogenesis 100%
• Synaptobrevin 2 100%
• Gel Permeation Chromatography 100%

Biochemistry, Genetics and Molecular Biology

• Mouse Model 100%
• Homogenate 100%
• Brain Homogenate 66%
• Amyloid Beta 33%
• MTT Assay 33%
• Size-Exclusion Chromatography 33%
• Molecular Weight 33%
• VAMP2 33%
• Synaptogenesis 33%
• Nerve Cell Plasticity 33%
• 3XTg Mouse 33%
• Glutamic Acid 33%