@article{a0ad0f0b7e73438d852f918cce13cd6e,
title = "Little Change in Functional Brain Networks Following Acute Levodopa in Drug-Na{\"i}ve Parkinson's Disease",
abstract = "Objective: The objective of this study was to investigate the effects of levodopa on functional brain networks in Parkinson's disease. Methods: We acquired resting state functional magnetic resonance imaging in 30 drug-na{\"i}ve participants with Parkinson's disease and 20 age-matched healthy controls. Each participant was studied following administration of a single oral dose of either levodopa or placebo in a randomized, double-blind, crossover design. Results: The greatest observed differences in functional connectivity were between Parkinson's disease versus control participants, independent of pharmacologic intervention. By contrast, the effects of levodopa were much smaller and detectable only in the Parkinson's disease group. Moreover, although levodopa administration in the Parkinson's disease group measurably improved motor performance, it did not increase the similarity of functional connectivity in Parkinson's disease to the control group. Conclusions: We found that a single, small dose of levodopa did not normalize functional connectivity in drug-na{\"i}ve Parkinson's disease.",
keywords = "Parkinson's disease, drug naive, fMRI, levodopa, resting-state functional connectivity",
author = "White, {Robert L.} and Campbell, {Meghan C.} and Dake Yang and William Shannon and Snyder, {Abraham Z.} and Perlmutter, {Joel S.}",
note = "Funding Information: We greatly appreciate the assistance of study coordinators Johanna Hartlein, Phil Lintzenich, Stacy Pratt, Yan Ling, and Thomas Belcher. We thank Ben Seitzman, Ashley Nielsen, and Deanna Greene for providing the region of interest set. This study was funded by the St. Louis Chapter of the American Parkinson Disease Association. Funding Information: R.L.W. reports employment with Department of Veteran's Affairs and Washington University. M.C.C. reports employment with Washington University and grants from the National Institutes of Health (NIH) and Washington University. D.Y. and W.S. report employment with BioRankings, LLC. A.Z.S. reports employment with Washington University and grants from the NIH and James S. McDonnell Foundation. J.S.P. reports employment with Washington University; grants from the NIH, American Parkinson Disease Association, Greater St. Louis Chapter of the APDA, Huntington Disease Society of America, Barnes‐Jewish Hospital Foundation, CHDI Foundation, M.J. Fox Foundation, U Michigan, Toronto Western University, Paula and Rodger Riney Foundation, Jo Oertli Foundation, and Murphy Fund; honoraria from University of Rochester, American Academy of Neurology, Movement Disorders Society, Emory University, Parkinson Foundation, St. Louis University, Harvard University, Stanford University, University of Florida at Gainesville, Huntington Study Group, and University of Pennsylvania; and medical legal consultations. Funding Information: We greatly appreciate the assistance of study coordinators Johanna Hartlein, Phil Lintzenich, Stacy Pratt, Yan Ling, and Thomas Belcher. We thank Ben Seitzman, Ashley Nielsen, and Deanna Greene for providing the region of interest set. This study was funded by the St. Louis Chapter of the American Parkinson Disease Association. Publisher Copyright: {\textcopyright} 2019 International Parkinson and Movement Disorder Society",
year = "2020",
month = mar,
day = "1",
doi = "10.1002/mds.27942",
language = "English",
volume = "35",
pages = "499--503",
journal = "Movement Disorders",
issn = "0885-3185",
number = "3",
}