Lithium protects against glucocorticoid induced neural progenitor cell apoptosis in the developing cerebellum

Omar Cabrera, Joseph Dougherty, Sukrit Singh, Brant S. Swiney, Nuri B. Farber, Kevin K. Noguchi

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Respiratory dysfunction is one of the most common causes of death associated with premature birth (Barton et al., 1999). In the United States, 7-10% of pregnant women receive antenatal glucocorticoid (GC) therapy (Matthews et al., 2004), while approximately 19% of very low birth weight infants receive postnatal GC therapy (Jobe, 2009). Clinical research suggests that GC treatment causes permanent neuromotor and cognitive deficits (Yeh et al., 2004) and stunts cerebellar growth (Parikh et al., 2007; Tam et al., 2011). We previously reported that GC-mediated neural progenitor cell (NPC) apoptosis may be responsible for cerebellar neuropathology (Maloney et al., 2011; Noguchi et al., 2008, 2011). The goal of the current study was to determine whether lithium protects NPCs from GC neuroapoptosis in vivo and in vitro. Given that it protects against a range of brain insults, we hypothesized that lithium would significantly attenuate GC induced NPC toxicity. We report that acute lithium pretreatment provides potent, cell-intrinsic neuroprotection against GC induced NPC toxicity in vivo and in vitro.

Original languageEnglish
Pages (from-to)54-63
Number of pages10
JournalBrain Research
Volume1545
DOIs
StatePublished - Jan 30 2014

Keywords

  • Apoptosis
  • Cerebellum
  • Dexamethasone
  • External granule layer
  • Glucocorticoid
  • Lithium
  • Neural progenitor cell
  • Neuroprotection

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