Lisdexamfetamine Dimesylate Effects on Binge Eating Behaviour and Obsessive-Compulsive and Impulsive Features in Adults with Binge Eating Disorder

Susan L. McElroy, James E. Mitchell, Denise Wilfley, Maria Gasior, M. Celeste Ferreira-Cornwell, Michael McKay, Jiannong Wang, Timothy Whitaker, James I. Hudson

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

In a published 11-week, placebo-controlled trial, 50 and 70 mg/d lisdexamfetamine dimesylate (LDX), but not 30 mg/d LDX, significantly reduced binge eating days (primary endpoint) in adults with binge eating disorder (BED). This report provides descriptions of LDX effects on secondary endpoints (Binge Eating Scale [BES]; Three-Factor Eating Questionnaire [TFEQ]; Yale-Brown Obsessive Compulsive Scale modified for Binge Eating [Y-BOCS-BE]; and the Barratt Impulsiveness Scale, version 11 [BIS-11]) from that study. Week 11 least squares mean treatment differences favoured all LDX doses over placebo on the BES (p ≤ 0.03), TFEQ Disinhibition and Hunger subscales (all p < 0.05), and Y-BOCS-BE total, obsessive, and compulsive scales (all p ≤ 0.02) and on BIS-11 total score at 70 mg/d LDX (p = 0.015) and the TFEQ Cognitive Restraint subscale at 30 and 70 mg/d LDX (both p<0.05). These findings indicate that LDX decreased global binge eating severity and obsessive-compulsive and impulsive features of BED in addition to binge eating days.

Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalEuropean Eating Disorders Review
Volume24
Issue number3
DOIs
StatePublished - May 1 2016

Keywords

  • binge eating disorder
  • impulsivity
  • lisdexamfetamine dimesylate
  • obsessive-compulsive

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    McElroy, S. L., Mitchell, J. E., Wilfley, D., Gasior, M., Ferreira-Cornwell, M. C., McKay, M., Wang, J., Whitaker, T., & Hudson, J. I. (2016). Lisdexamfetamine Dimesylate Effects on Binge Eating Behaviour and Obsessive-Compulsive and Impulsive Features in Adults with Binge Eating Disorder. European Eating Disorders Review, 24(3), 223-231. https://doi.org/10.1002/erv.2418