Liquid Chromatographic Separation of Diastereomers and Structural Isomers on Cyclodextrin-Bonded Phases

Daniel W. Armstrong, Wade DeMond, Ala Alak, Willie L. Hinze, Terrence E. Riehl, Khanh H. Bui

Research output: Contribution to journalArticlepeer-review

153 Scopus citations

Abstract

Eighty compounds are separated from their Isomers by LC using cyclodextrln-bonded columns. A variety of structural Isomers (including polycyclic aromatic hydrocarbons and prostaglandins), geometric Isomers, and steroid epimers are examined. Cyclodextrin-bonded packings appear to be more widely applicable than either normal or reversed-phase packings for these types of separations. Indeed, compounds that cannot be well resolved on more traditional columns are often easily separated on this stationary phase. The separation mechanism Is based on Inclusion complex formation and is responsible for the unusual but often predictable selectlvlties observed.

Original languageEnglish
Pages (from-to)234-237
Number of pages4
JournalAnalytical Chemistry
Volume57
Issue number1
DOIs
StatePublished - Jan 1 1985

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