Liquid Biopsies Using Circulating Tumor DNA in Non-Small Cell Lung Cancer

Bruna Pellini, Jeffrey Szymanski, Re I. Chin, Paul A. Jones, Aadel A. Chaudhuri

Research output: Contribution to journalReview article

Abstract

Liquid biopsies for the diagnosis and treatment of lung cancer have developed rapidly, driven primarily by technical advances in sensitivity to detect circulating tumor DNA (ctDNA). Still, technical limitations such as the challenge of detecting low-level ctDNA variants and distinguishing tumor-related variants from clonal hematopoiesis remain. With further technical advancements, new applications for ctDNA analysis are emerging including detection of post-treatment molecular residual disease (MRD), clinical trial selection, and early cancer detection. This chapter reviews the current state of ctDNA testing in NSCLC, the underlying technological advances enabling ctDNA detection, and the potential to expand ctDNA analysis to new applications.

Original languageEnglish
Pages (from-to)165-177
Number of pages13
JournalThoracic surgery clinics
Volume30
Issue number2
DOIs
StatePublished - May 1 2020

Keywords

  • Circulating tumor DNA (ctDNA)
  • Liquid biopsy
  • Non-small cell lung cancer (NSCLC)
  • Plasma genotyping

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