Liquid biopsies for residual disease and recurrence

Jonathan Chee Ming Wan, Tariq Imdadali Mughal, Pedram Razavi, Sarah Jane Dawson, Esther Louise Moss, Ramaswamy Govindan, Iain Beehuat Tan, Yoon Sim Yap, William Allen Robinson, Clive Dylan Morris, Benjamin Besse, Alberto Bardelli, Jeanne Tie, Scott Kopetz, Nitzan Rosenfeld

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Detection of minimal residual disease in patients with cancer, who are in complete remission with no cancer cells detectable, has the potential to improve recurrence-free survival through treatment selection. Studies analyzing circulating tumor DNA (ctDNA) in patients with solid tumors suggest the potential to accurately predict and detect relapse, enabling treatment strategies that may improve clinical outcomes. Over the past decade, assays for ctDNA detection in plasma samples have steadily increased in sensitivity and specificity. These are applied for the detection of residual disease after treatment and for earlier detection of recurrence. Novel clinical trials are now assessing how assays for “residual disease and recurrence” (RDR) may influence current treatment paradigms and potentially change the landscape of risk classification for cancer recurrence. In this review, we appraise the progress of RDR detection using ctDNA and consider the emerging role of liquid biopsy in the monitoring and management of solid tumors.

Original languageEnglish
Pages (from-to)1292-1313
Number of pages22
Issue number12
StatePublished - Dec 10 2021


  • MRD
  • RDR
  • clinical trials
  • ctDNA
  • residual disease and recurrence
  • solid tumors


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