Liquid biomarkers for early detection of prostate cancer and summary of available data for their use in African-American men

Grant M. Henning, Gerald L. Andriole, Eric H. Kim

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Background: Several liquid biomarker tests have been developed to account for the limitations of prostate specific antigen (PSA) screening prior to prostate biopsy. African ancestry is an established risk factor for prostate cancer (PCa) and must be particularly considered when evaluating patients with liquid biomarkers. While multiple tests have been developed over decades of exploration, recent advances can help patients and physicians incorporate data into a broader clinical context. Methods: We sought to review currently available liquid biomarker tests in a practical, clinically directed fashion with particular focus on performance in men with African ancestry. We reviewed discovery and validation studies and highlight important considerations for each test. Results: We discuss the advantages and limitations of percent free PSA, Prostate Health Index, Progensa® PCA3, ExoDx® Prostate Test, SelectMDx®, 4Kscore® Test, and Mi-Prostate Score and summarize salient studies on their use. A literature review of evidence specifically for men with African ancestry was conducted and available studies were summarized. Conclusions: Liquid biomarkers can be useful tools for aiding in risk stratification prior to prostate biopsy. Use of such tests should be individualized based on a thorough knowledge of supporting evidence and the goals of the patient and physician. Further study should prioritize evaluation of such biomarkers in men with African ancestry.

Original languageEnglish
Pages (from-to)180-186
Number of pages7
JournalProstate Cancer and Prostatic Diseases
Volume25
Issue number2
DOIs
StatePublished - Feb 2022

Fingerprint

Dive into the research topics of 'Liquid biomarkers for early detection of prostate cancer and summary of available data for their use in African-American men'. Together they form a unique fingerprint.

Cite this