TY - JOUR
T1 - Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway
AU - Waltz, Paul
AU - Carchman, Evie H.
AU - Young, Atalie C.
AU - Rao, Jayashree
AU - Rosengart, Matthew R.
AU - Kaczorowski, David
AU - Zuckerbraun, Brian S.
PY - 2011/3
Y1 - 2011/3
N2 - Toll-like receptor (TLR) signaling is an important part of the innate immune response. One of the downstream responses to TLR4 signaling upon lipopolysaccharide (LPS) stimulation is the induction of autophagy, which is a key response to multiple stressors. An additional adaptive signaling molecule that is involved in the response to stress is heme oxygenase-1 (HO-1). HO-1 signaling is essential to limit inflammation and restore homeostasis. We found that LPS induced autophagic signaling in macrophages via a TLR4, HO-1 dependent pathway in macrophages. These data add to the developing contribution of autophagic signaling as part of the inflammatory response.
AB - Toll-like receptor (TLR) signaling is an important part of the innate immune response. One of the downstream responses to TLR4 signaling upon lipopolysaccharide (LPS) stimulation is the induction of autophagy, which is a key response to multiple stressors. An additional adaptive signaling molecule that is involved in the response to stress is heme oxygenase-1 (HO-1). HO-1 signaling is essential to limit inflammation and restore homeostasis. We found that LPS induced autophagic signaling in macrophages via a TLR4, HO-1 dependent pathway in macrophages. These data add to the developing contribution of autophagic signaling as part of the inflammatory response.
KW - Peritoneal macrophages
KW - RAW 264.7
KW - Sepsis
KW - Tumor necrosis factoralpha
UR - http://www.scopus.com/inward/record.url?scp=79952357209&partnerID=8YFLogxK
U2 - 10.4161/auto.7.3.14044
DO - 10.4161/auto.7.3.14044
M3 - Article
C2 - 21307647
AN - SCOPUS:79952357209
SN - 1554-8627
VL - 7
SP - 315
EP - 320
JO - Autophagy
JF - Autophagy
IS - 3
ER -