TY - JOUR
T1 - Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania
AU - Beverley, Stephen M.
AU - Turco, Salvatore J.
N1 - Funding Information:
Acknowledgements Wet hankP .C otrimA, . DescoteauLx. ,E pstein, B. Mengeling, D. Sacks and H. Xu for providing unpublished results, D. Dobson and B. Mengeling for helpful comments on this manuscript, and H. Avila and A. Bray for assistancein preparing the figures. This work was supported by NIH grants AI29646 and 31078.
PY - 1998/1
Y1 - 1998/1
N2 - Leishmania exploits several strategies to survive within the phagolysosome of vertebrate macrophages and be transmitted by sand fly vectors. Recent advances in functional genetic analysis provide a new avenue for identifying genes implicated in the infectious cycle of the parasite, such as those necessary for the synthesis and expression of the key surface glycoconjugate, lipophosphoglycan (LPG).
AB - Leishmania exploits several strategies to survive within the phagolysosome of vertebrate macrophages and be transmitted by sand fly vectors. Recent advances in functional genetic analysis provide a new avenue for identifying genes implicated in the infectious cycle of the parasite, such as those necessary for the synthesis and expression of the key surface glycoconjugate, lipophosphoglycan (LPG).
UR - http://www.scopus.com/inward/record.url?scp=0031939025&partnerID=8YFLogxK
U2 - 10.1016/S0966-842X(97)01180-3
DO - 10.1016/S0966-842X(97)01180-3
M3 - Review article
C2 - 9481823
AN - SCOPUS:0031939025
VL - 6
SP - 35
EP - 40
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
IS - 1
ER -