Lipophilic pyridinium bisphosphonates: Potent γδ t cell stimulators

Yonghui Zhang; Rong Cao; Fenglin Yin; Fu Yang Lin; Hong Wang; Kilannin Krysiak; Joo Hwan No; Dushyant Mukkamala; Kevin Houlihan; Jikun Li; Craig T. Morita; Eric Oldfield

doi:10.1002/anie.200905933

Lipophilic pyridinium bisphosphonates: Potent γδ t cell stimulators

Yonghui Zhang, Rong Cao, Fenglin Yin, Fu Yang Lin, Hong Wang, Kilannin Krysiak, Joo Hwan No, Dushyant Mukkamala, Kevin Houlihan, Jikun Li, Craig T. Morita, Eric Oldfield

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Chain gang: Lipophilic pyridinium bisphosphonates containing long alkyl chains (see picture, P red, N blue, C orange, H gray) stimulate human γδ T cells expressing the Vγ2Vδ2 T cell receptor. Stimulation with such compounds is more potent than with zoledronate, which is active against breast and prostate cancer. The lipophilic bisphosphonates bind poorly to bone and are thus less likely to cause side effects associated with bisphosphonates in clinical use. Figure Presented

Original language	English
Pages (from-to)	1136-1138
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	6
DOIs	https://doi.org/10.1002/anie.200905933
State	Published - Feb 1 2010

Keywords

Bisphosphonates
Immunology
Inhibitors
Terpenoids

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10.1002/anie.200905933

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title = "Lipophilic pyridinium bisphosphonates: Potent γδ t cell stimulators",

abstract = "Chain gang: Lipophilic pyridinium bisphosphonates containing long alkyl chains (see picture, P red, N blue, C orange, H gray) stimulate human γδ T cells expressing the Vγ2Vδ2 T cell receptor. Stimulation with such compounds is more potent than with zoledronate, which is active against breast and prostate cancer. The lipophilic bisphosphonates bind poorly to bone and are thus less likely to cause side effects associated with bisphosphonates in clinical use. Figure Presented",

keywords = "Bisphosphonates, Immunology, Inhibitors, Terpenoids",

author = "Yonghui Zhang and Rong Cao and Fenglin Yin and Lin, {Fu Yang} and Hong Wang and Kilannin Krysiak and No, {Joo Hwan} and Dushyant Mukkamala and Kevin Houlihan and Jikun Li and Morita, {Craig T.} and Eric Oldfield",

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T1 - Lipophilic pyridinium bisphosphonates

T2 - Potent γδ t cell stimulators

AU - Zhang, Yonghui

AU - Cao, Rong

AU - Yin, Fenglin

AU - Lin, Fu Yang

AU - Wang, Hong

AU - Krysiak, Kilannin

AU - No, Joo Hwan

AU - Mukkamala, Dushyant

AU - Houlihan, Kevin

AU - Li, Jikun

AU - Morita, Craig T.

AU - Oldfield, Eric

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Chain gang: Lipophilic pyridinium bisphosphonates containing long alkyl chains (see picture, P red, N blue, C orange, H gray) stimulate human γδ T cells expressing the Vγ2Vδ2 T cell receptor. Stimulation with such compounds is more potent than with zoledronate, which is active against breast and prostate cancer. The lipophilic bisphosphonates bind poorly to bone and are thus less likely to cause side effects associated with bisphosphonates in clinical use. Figure Presented

AB - Chain gang: Lipophilic pyridinium bisphosphonates containing long alkyl chains (see picture, P red, N blue, C orange, H gray) stimulate human γδ T cells expressing the Vγ2Vδ2 T cell receptor. Stimulation with such compounds is more potent than with zoledronate, which is active against breast and prostate cancer. The lipophilic bisphosphonates bind poorly to bone and are thus less likely to cause side effects associated with bisphosphonates in clinical use. Figure Presented

KW - Bisphosphonates

KW - Immunology

KW - Inhibitors

KW - Terpenoids

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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Lipophilic pyridinium bisphosphonates: Potent γδ t cell stimulators

Abstract

Keywords

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