Lipophilic pyridinium bisphosphonates: Potent γδ t cell stimulators

Yonghui Zhang, Rong Cao, Fenglin Yin, Fu Yang Lin, Hong Wang, Kilannin Krysiak, Joo Hwan No, Dushyant Mukkamala, Kevin Houlihan, Jikun Li, Craig T. Morita, Eric Oldfield

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Chain gang: Lipophilic pyridinium bisphosphonates containing long alkyl chains (see picture, P red, N blue, C orange, H gray) stimulate human γδ T cells expressing the Vγ2Vδ2 T cell receptor. Stimulation with such compounds is more potent than with zoledronate, which is active against breast and prostate cancer. The lipophilic bisphosphonates bind poorly to bone and are thus less likely to cause side effects associated with bisphosphonates in clinical use. Figure Presented

Original languageEnglish
Pages (from-to)1136-1138
Number of pages3
JournalAngewandte Chemie - International Edition
Volume49
Issue number6
DOIs
StatePublished - Feb 1 2010

Keywords

  • Bisphosphonates
  • Immunology
  • Inhibitors
  • Terpenoids

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