TY - JOUR
T1 - Lipolytic sensitivity and response to fasting in normotensive and hypertensive obese humans
AU - Townsend, Raymond R.
AU - Klein, Samuel
N1 - Funding Information:
From the Department of Internal Medicine, University of Pennsylvania Medical Center, Philadelphia, PA; and the Department of Internal Medicine, Washington University School of Medicine, St Louis, MO. Submitted October 9, 1996; accepted April 6, 1997. Supported by National Institutes of Health (NIH) Grant No. DK-49989, General Clinical Research Center Grant No. RR-O0073, NIH Training Grant No. DK-07006, and administrative/educational funds from the Dialysis Clinics Incorporated Renal Education and Development fund. Address reprint requests to Raymond R. Townsend, MD, University of Pennsylvania Medical Center, 210 White Bldg, 3400 Spruce St, Philadelphia, PA 19104. Copyright © 1997 by W.B. Saunders Company 0026-0495/97/4609-0019503.00/0
PY - 1997
Y1 - 1997
N2 - Obese persons with hypertension are at greater risk for diabetes and hyperlipidemia than normotensive obese persons. It has been postulated that increased lipolytic rates contribute to these metabolic diseases. Therefore, we evaluated the glycerol rate of appearance (Ra) in plasma, an index of whole-body lipolytic activity, during basal conditions and during 60 minutes of epinephrine infusion after 12 and 84 hours of fasting in six normotensive (body mass index [BMI], 39.8 ± 1.8 kg/m2) and six hypertensive (BMI, 38.7 ± 1.6 kg/m2) obese persons. Basal glycerol Ra was lower in hypertensive than in normotensive subjects at both 12 hours [1.58 ± 0.21 v2.27 ± 0.26 μmol/kg/min, respectively; P < .01) and 84 hours (2.04 ± 0.06 v2.50 ± 0.13 μmol/kg/min, respectively; P < .01) of fasting. Peak glycerol Ra during epinephrine infusion after 84 hours of fasting (5.69 ± 0.72 and 11.40 ± 0.78 μmol/kg/min for hypertensive and normotensive subjects, respectively(was significantly greater than at 12 hours (3.09 ± 0.29 and 5.06 ± 0.69 μmol/kg/min) in both hypertensive and normotensive subjects. However, peak glycerol Ra was lower in hypertensive than in normotensive subjects after 12 and 84 hours of fasting (P < .01 for 84 hours(. We conclude that hypertension in obese persons is associated with a decrease in both basal lipolytic rates and lipolytic sensitivity to epinephrine infusion.
AB - Obese persons with hypertension are at greater risk for diabetes and hyperlipidemia than normotensive obese persons. It has been postulated that increased lipolytic rates contribute to these metabolic diseases. Therefore, we evaluated the glycerol rate of appearance (Ra) in plasma, an index of whole-body lipolytic activity, during basal conditions and during 60 minutes of epinephrine infusion after 12 and 84 hours of fasting in six normotensive (body mass index [BMI], 39.8 ± 1.8 kg/m2) and six hypertensive (BMI, 38.7 ± 1.6 kg/m2) obese persons. Basal glycerol Ra was lower in hypertensive than in normotensive subjects at both 12 hours [1.58 ± 0.21 v2.27 ± 0.26 μmol/kg/min, respectively; P < .01) and 84 hours (2.04 ± 0.06 v2.50 ± 0.13 μmol/kg/min, respectively; P < .01) of fasting. Peak glycerol Ra during epinephrine infusion after 84 hours of fasting (5.69 ± 0.72 and 11.40 ± 0.78 μmol/kg/min for hypertensive and normotensive subjects, respectively(was significantly greater than at 12 hours (3.09 ± 0.29 and 5.06 ± 0.69 μmol/kg/min) in both hypertensive and normotensive subjects. However, peak glycerol Ra was lower in hypertensive than in normotensive subjects after 12 and 84 hours of fasting (P < .01 for 84 hours(. We conclude that hypertension in obese persons is associated with a decrease in both basal lipolytic rates and lipolytic sensitivity to epinephrine infusion.
UR - http://www.scopus.com/inward/record.url?scp=0030866916&partnerID=8YFLogxK
U2 - 10.1016/S0026-0495(97)90282-1
DO - 10.1016/S0026-0495(97)90282-1
M3 - Article
C2 - 9284900
AN - SCOPUS:0030866916
SN - 0026-0495
VL - 46
SP - 1080
EP - 1084
JO - Metabolism: clinical and experimental
JF - Metabolism: clinical and experimental
IS - 9
ER -