To determine whether the sensitivity of adipose tissue lipolysis to catecholamines is increased in poorly controlled insulin-dependent diabetes, the lipolytic response to epinephrine was measured in seven nondiabetic volunteers and seven poorly controlled diabetic subjects with use of [1- 14C]palmitate as a tracer. Subjects received sequential 1-h infusions of epinephrine, which produced epinephrine concentrations of ~1,000, ~1,750, ~3,500, and ~6,000 pmol/l. A pancreatic clamp was used to maintain constant plasma hormone levels. Concentration-response curves were constructed for each subject from the integrated lipolytic response during each epinephrine infusion. There was no difference in maximal lipolytic response (117 ± 19 vs. 152 ± 11 μmol · kg-1 · h-1) or in maximally effective (3,171 ± 267 vs. 3,357 ± 349 pmol/l) or half-maximally effective (1,081 ± 109 vs. 1,015 ± 120 pmol/l) epinephrine concentrations between nondiabetic and diabetic subjects, respectively (all P = NS). In control subjects, maximum β-hydroxybutyrate concentrations were achieved at lower epinephrine concentrations than those required for a maximum lipolytic effect. Thus, under pancreatic clamp conditions, the lipolytic response to epinephrine in nondiabetic and diabetic subjects was similar.
|Journal||American Journal of Physiology - Endocrinology and Metabolism|
|Issue number||6 35-6|
|State||Published - Jun 1997|
- Free fatty acids
- Insulin-dependent diabetes mellitus