Lipid Regulators of Thermogenic Fat Activation

Hongsuk Park, Anyuan He, Irfan J. Lodhi

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

The global prevalence of obesity continues to increase, suggesting a need for alternative treatment approaches. Targeting brown fat function to promote energy expenditure represents one such approach. Brown adipocytes and the related beige adipocytes oxidize fatty acids and glucose to generate heat and are activated by cold exposure or consumption of high-calorie diets. Alternative, more practical means to activate thermogenic fat are needed. Here, we review emerging data suggesting new roles for lipids in activating thermogenesis that extend beyond their serving as a fuel source for heat generation. Lipids have also been implicated in mediating interorgan communication, crosstalk between organelles, and cellular signaling regulating thermogenesis. Understanding how lipids regulate thermogenesis could identify innovative therapeutic interventions for obesity.

Original languageEnglish
Pages (from-to)710-723
Number of pages14
JournalTrends in Endocrinology and Metabolism
Volume30
Issue number10
DOIs
StatePublished - Oct 2019

Keywords

  • beige fat
  • brown adipose tissue
  • mitochondria
  • obesity
  • plasmalogen
  • thermogenesis

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