Lipid rafts in neuronal signaling and function

Brian A. Tsui-Pierchala, Mario Encinas, Jeffrey Milbrandt, Eugene M. Johnson

Research output: Contribution to journalReview articlepeer-review

287 Scopus citations

Abstract

Lipid rafts are plasma membrane microdomains rich in cholesterol and sphingolipids, which provide a particularly ordered lipid environment. Rafts are enriched in glycosylphosphatidylinositol (GPI)-anchored proteins, as well as proteins involved in signal transduction and intracellular trafficking. In neurons, lipid rafts act as platforms for the signal transduction initiated by several classes of neurotrophic factors, including neurotrophins and glial-derived neurotrophic factor (GDNF)-family ligands. Emerging evidence also indicates that such rafts are important for neuronal cell adhesion, axon guidance and synaptic transmission. Thus, lipid rafts are structurally unique components of plasma membranes, crucial for neural development and function.

Original languageEnglish
Pages (from-to)412-417
Number of pages6
JournalTrends in Neurosciences
Volume25
Issue number8
DOIs
StatePublished - Aug 1 2002

Fingerprint Dive into the research topics of 'Lipid rafts in neuronal signaling and function'. Together they form a unique fingerprint.

Cite this