Lipid rafts are established as critical structures for a variety of cellular processes, including immune cell activation. Beyond their importance for initial immune cell activation at the immunological synapse, lipid rafts are now also being recognized as important sites for cytokine and growth factor signal transduction, both in immune cells as part of secondary regulatory processes, and in non-immune cells. This review summarizes current knowledge regarding the roles of rafts in cytokine signaling and emphasizes the need for measures to better standardize the study of rafts.
- Antigen presenting cells
- Cholera toxin B subunit
- Common cytokine receptor γ-chain
- Immunological synapse
- Interferon-γ receptor
- Janus protein tyrosine kinase