Lipid rafts in cytokine signaling

Rakesh Rao; Barbara Logan; Kathy Forrest; Thomas L. Roszman; Jens Goebel

doi:10.1016/j.cytogfr.2004.01.003

Lipid rafts in cytokine signaling

Rakesh Rao, Barbara Logan, Kathy Forrest, Thomas L. Roszman, Jens Goebel

Research output: Contribution to journal › Short survey › peer-review

21 Scopus citations

Abstract

Lipid rafts are established as critical structures for a variety of cellular processes, including immune cell activation. Beyond their importance for initial immune cell activation at the immunological synapse, lipid rafts are now also being recognized as important sites for cytokine and growth factor signal transduction, both in immune cells as part of secondary regulatory processes, and in non-immune cells. This review summarizes current knowledge regarding the roles of rafts in cytokine signaling and emphasizes the need for measures to better standardize the study of rafts.

Original language	English
Pages (from-to)	103-110
Number of pages	8
Journal	Cytokine and Growth Factor Reviews
Volume	15
Issue number	2-3
DOIs	https://doi.org/10.1016/j.cytogfr.2004.01.003
State	Published - Apr 2004

Keywords

APC
Antigen presenting cells
CTB
Cholera toxin B subunit
Common cytokine receptor γ-chain
GPI
Glycosylphosphatidylinositol
IFNGR
IS
Immunological synapse
Interferon-γ receptor
Jak
Janus protein tyrosine kinase
MBCD
γ

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10.1016/j.cytogfr.2004.01.003

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title = "Lipid rafts in cytokine signaling",

abstract = "Lipid rafts are established as critical structures for a variety of cellular processes, including immune cell activation. Beyond their importance for initial immune cell activation at the immunological synapse, lipid rafts are now also being recognized as important sites for cytokine and growth factor signal transduction, both in immune cells as part of secondary regulatory processes, and in non-immune cells. This review summarizes current knowledge regarding the roles of rafts in cytokine signaling and emphasizes the need for measures to better standardize the study of rafts.",

keywords = "APC, Antigen presenting cells, CTB, Cholera toxin B subunit, Common cytokine receptor γ-chain, GPI, Glycosylphosphatidylinositol, IFNGR, IS, Immunological synapse, Interferon-γ receptor, Jak, Janus protein tyrosine kinase, MBCD, γ",

author = "Rakesh Rao and Barbara Logan and Kathy Forrest and Roszman, {Thomas L.} and Jens Goebel",

note = "Funding Information: We dedicate this review to K.F.{\textquoteright}s and R.R.{\textquoteright}s baby daughters Kaylee-Marie and Soumya. It was supported by the Department of Pediatrics, University of Kentucky, through a Children{\textquoteright}s Miracle Network grant and through other mechanisms, by a Physician–Scientist Award from the University of Kentucky Hospital, by a Bristol Myers Squibb Young Investigator Award from the National Kidney Foundation, and by NIH grant 1 KO8AI049241-01A1, all to J.G.",

year = "2004",

month = apr,

doi = "10.1016/j.cytogfr.2004.01.003",

language = "English",

volume = "15",

pages = "103--110",

journal = "Cytokine and Growth Factor Reviews",

issn = "1359-6101",

number = "2-3",

}

TY - JOUR

T1 - Lipid rafts in cytokine signaling

AU - Rao, Rakesh

AU - Logan, Barbara

AU - Forrest, Kathy

AU - Roszman, Thomas L.

AU - Goebel, Jens

N1 - Funding Information: We dedicate this review to K.F.’s and R.R.’s baby daughters Kaylee-Marie and Soumya. It was supported by the Department of Pediatrics, University of Kentucky, through a Children’s Miracle Network grant and through other mechanisms, by a Physician–Scientist Award from the University of Kentucky Hospital, by a Bristol Myers Squibb Young Investigator Award from the National Kidney Foundation, and by NIH grant 1 KO8AI049241-01A1, all to J.G.

PY - 2004/4

Y1 - 2004/4

N2 - Lipid rafts are established as critical structures for a variety of cellular processes, including immune cell activation. Beyond their importance for initial immune cell activation at the immunological synapse, lipid rafts are now also being recognized as important sites for cytokine and growth factor signal transduction, both in immune cells as part of secondary regulatory processes, and in non-immune cells. This review summarizes current knowledge regarding the roles of rafts in cytokine signaling and emphasizes the need for measures to better standardize the study of rafts.

AB - Lipid rafts are established as critical structures for a variety of cellular processes, including immune cell activation. Beyond their importance for initial immune cell activation at the immunological synapse, lipid rafts are now also being recognized as important sites for cytokine and growth factor signal transduction, both in immune cells as part of secondary regulatory processes, and in non-immune cells. This review summarizes current knowledge regarding the roles of rafts in cytokine signaling and emphasizes the need for measures to better standardize the study of rafts.

KW - APC

KW - Antigen presenting cells

KW - CTB

KW - Cholera toxin B subunit

KW - Common cytokine receptor γ-chain

KW - GPI

KW - Glycosylphosphatidylinositol

KW - IFNGR

KW - IS

KW - Immunological synapse

KW - Interferon-γ receptor

KW - Jak

KW - Janus protein tyrosine kinase

KW - MBCD

KW - γ

UR - http://www.scopus.com/inward/record.url?scp=1942541221&partnerID=8YFLogxK

U2 - 10.1016/j.cytogfr.2004.01.003

DO - 10.1016/j.cytogfr.2004.01.003

M3 - Short survey

C2 - 15110794

AN - SCOPUS:1942541221

SN - 1359-6101

VL - 15

SP - 103

EP - 110

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 2-3

ER -

Lipid rafts in cytokine signaling

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Keywords

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