Linking transcriptional silencing with chromatin remodeling, folding, and positioning in the nucleus

Zhang Wei Liu, Carl H. Simmons, Xuehua Zhong

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Chromatin organization is important for many DNA-templated processes in eukaryotic cells such as replication and transcription. Recent studies have uncovered the capacity of epigenetic modifications, phase separation, and nuclear architecture and spatial positioning to regulate chromatin organization in both plants and animals. Here, we provide an overview of the recent progress made in understanding how chromatin is organized within the nucleus at both the local and global levels with respect to the regulation of transcriptional silencing in plants. To be concise while covering important mechanisms across a range of scales, we focus on how epigenetic modifications and chromatin remodelers alter local chromatin structure, how liquid-liquid phase separation physically separates broader chromatin domains into distinct droplets, and how nuclear positioning affects global chromatin organization.

Original languageEnglish
Article number102261
JournalCurrent Opinion in Plant Biology
Volume69
DOIs
StatePublished - Oct 2022

Keywords

  • Chromatin organization
  • Epigenetic modifications
  • Transcriptional regulation

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