TY - JOUR
T1 - Linking transcriptional silencing with chromatin remodeling, folding, and positioning in the nucleus
AU - Liu, Zhang Wei
AU - Simmons, Carl H.
AU - Zhong, Xuehua
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/10
Y1 - 2022/10
N2 - Chromatin organization is important for many DNA-templated processes in eukaryotic cells such as replication and transcription. Recent studies have uncovered the capacity of epigenetic modifications, phase separation, and nuclear architecture and spatial positioning to regulate chromatin organization in both plants and animals. Here, we provide an overview of the recent progress made in understanding how chromatin is organized within the nucleus at both the local and global levels with respect to the regulation of transcriptional silencing in plants. To be concise while covering important mechanisms across a range of scales, we focus on how epigenetic modifications and chromatin remodelers alter local chromatin structure, how liquid-liquid phase separation physically separates broader chromatin domains into distinct droplets, and how nuclear positioning affects global chromatin organization.
AB - Chromatin organization is important for many DNA-templated processes in eukaryotic cells such as replication and transcription. Recent studies have uncovered the capacity of epigenetic modifications, phase separation, and nuclear architecture and spatial positioning to regulate chromatin organization in both plants and animals. Here, we provide an overview of the recent progress made in understanding how chromatin is organized within the nucleus at both the local and global levels with respect to the regulation of transcriptional silencing in plants. To be concise while covering important mechanisms across a range of scales, we focus on how epigenetic modifications and chromatin remodelers alter local chromatin structure, how liquid-liquid phase separation physically separates broader chromatin domains into distinct droplets, and how nuclear positioning affects global chromatin organization.
KW - Chromatin organization
KW - Epigenetic modifications
KW - Transcriptional regulation
UR - http://www.scopus.com/inward/record.url?scp=85134547568&partnerID=8YFLogxK
U2 - 10.1016/j.pbi.2022.102261
DO - 10.1016/j.pbi.2022.102261
M3 - Review article
C2 - 35841650
AN - SCOPUS:85134547568
SN - 1369-5266
VL - 69
JO - Current Opinion in Plant Biology
JF - Current Opinion in Plant Biology
M1 - 102261
ER -