Linking gradient echo plural contrast imaging metrics of tissue microstructure with Alzheimer disease

Dmitriy A. Yablonskiy; Tammie L. Benzinger; John C. Morris

doi:10.1016/B978-0-12-815868-5.00032-3

Linking gradient echo plural contrast imaging metrics of tissue microstructure with Alzheimer disease

Dmitriy A. Yablonskiy, Tammie L. Benzinger, John C. Morris

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

In this chapter we provide a brief overview of magnetic resonance imaging (MRI)-based gradient echo plural contrast imaging (GEPCI) technique and its applications to study Alzheimer disease (AD)-one of the major global health problems. GEPCI provides surrogates for quantitative assessments of AD-related changes in the brain tissue structure that are sensitive to accumulation of amyloid plaques and neuronal loss and can distinguish between healthy control, preclinical and mild stages of AD. GEPCI technique has also been applied for evaluating tissue damage in multiple sclerosis and some psychiatric diseases.

Original language	English
Title of host publication	Genetics, Neurology, Behavior, and Diet in Dementia
Subtitle of host publication	The Neuroscience of Dementia, Volume 2
Publisher	Elsevier
Pages	507-519
Number of pages	13
ISBN (Electronic)	9780128158685
DOIs	https://doi.org/10.1016/B978-0-12-815868-5.00032-3
State	Published - Jan 1 2020

Keywords

Alzheimer disease
Amyloid pathology
Brain atrophy
GEPCI
MRI
PET
Tau pathology

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10.1016/B978-0-12-815868-5.00032-3

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title = "Linking gradient echo plural contrast imaging metrics of tissue microstructure with Alzheimer disease",

abstract = "In this chapter we provide a brief overview of magnetic resonance imaging (MRI)-based gradient echo plural contrast imaging (GEPCI) technique and its applications to study Alzheimer disease (AD)-one of the major global health problems. GEPCI provides surrogates for quantitative assessments of AD-related changes in the brain tissue structure that are sensitive to accumulation of amyloid plaques and neuronal loss and can distinguish between healthy control, preclinical and mild stages of AD. GEPCI technique has also been applied for evaluating tissue damage in multiple sclerosis and some psychiatric diseases.",

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Linking gradient echo plural contrast imaging metrics of tissue microstructure with Alzheimer disease. / Yablonskiy, Dmitriy A.; Benzinger, Tammie L.; Morris, John C.
Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2. Elsevier, 2020. p. 507-519.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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KW - PET

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ER -

Linking gradient echo plural contrast imaging metrics of tissue microstructure with Alzheimer disease

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Keywords

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