In this chapter we provide a brief overview of magnetic resonance imaging (MRI)-based gradient echo plural contrast imaging (GEPCI) technique and its applications to study Alzheimer disease (AD)-one of the major global health problems. GEPCI provides surrogates for quantitative assessments of AD-related changes in the brain tissue structure that are sensitive to accumulation of amyloid plaques and neuronal loss and can distinguish between healthy control, preclinical and mild stages of AD. GEPCI technique has also been applied for evaluating tissue damage in multiple sclerosis and some psychiatric diseases.

Original languageEnglish
Title of host publicationGenetics, Neurology, Behavior, and Diet in Dementia
Subtitle of host publicationThe Neuroscience of Dementia, Volume 2
Number of pages13
ISBN (Electronic)9780128158685
StatePublished - Jan 1 2020


  • Alzheimer disease
  • Amyloid pathology
  • Brain atrophy
  • MRI
  • PET
  • Tau pathology


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