Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

Bernice Porjesz; Laura Almasy; Howard J. Edenberg; Kongming Wang; David B. Chorlian; Tatiana Foroud; Alison Goate; John P. Rice; Sean J. O'Connor; John Rohrbaugh; Samuel Kuperman; Lance O. Bauer; Raymond R. Crowe; Marc A. Schuckit; Victor Hesselbrock; P. Michael Conneally; Jay A. Tischfield; Ting Kai Li; Theodore Reich; Henri Begleiter

doi:10.1073/pnas.052716399

Linkage disequilibrium between the beta frequency of the human EEG and a GABA_A receptor gene locus

Bernice Porjesz
, Laura Almasy
, Howard J. Edenberg
, Kongming Wang
, David B. Chorlian
, Tatiana Foroud
, Alison Goate
, John P. Rice
, Sean J. O'Connor
, John Rohrbaugh
, Samuel Kuperman
, Lance O. Bauer
, Raymond R. Crowe
, Marc A. Schuckit
, Victor Hesselbrock
, P. Michael Conneally
, Jay A. Tischfield
, Ting Kai Li
, Theodore Reich
, Henri Begleiter

Research output: Contribution to journal › Article › peer-review

280 Scopus citations

Abstract

Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABA_A) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABA_A receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.

Original language	English
Pages (from-to)	3729-3733
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	99
Issue number	6
DOIs	https://doi.org/10.1073/pnas.052716399
State	Published - Mar 19 2002

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Porjesz, B., Almasy, L., Edenberg, H. J., Wang, K., Chorlian, D. B., Foroud, T., Goate, A., Rice, J. P., O'Connor, S. J., Rohrbaugh, J., Kuperman, S., Bauer, L. O., Crowe, R. R., Schuckit, M. A., Hesselbrock, V., Conneally, P. M., Tischfield, J. A., Li, T. K., Reich, T., & Begleiter, H. (2002). Linkage disequilibrium between the beta frequency of the human EEG and a GABA_A receptor gene locus. Proceedings of the National Academy of Sciences of the United States of America, 99(6), 3729-3733. https://doi.org/10.1073/pnas.052716399

@article{6b6a60d9e2e84d3cab1cece280defede,

title = "Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus",

abstract = "Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABAA) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABAA receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.",

author = "Bernice Porjesz and Laura Almasy and Edenberg, \{Howard J.\} and Kongming Wang and Chorlian, \{David B.\} and Tatiana Foroud and Alison Goate and Rice, \{John P.\} and O'Connor, \{Sean J.\} and John Rohrbaugh and Samuel Kuperman and Bauer, \{Lance O.\} and Crowe, \{Raymond R.\} and Schuckit, \{Marc A.\} and Victor Hesselbrock and Conneally, \{P. Michael\} and Tischfield, \{Jay A.\} and Li, \{Ting Kai\} and Theodore Reich and Henri Begleiter",

year = "2002",

month = mar,

day = "19",

doi = "10.1073/pnas.052716399",

language = "English",

volume = "99",

pages = "3729--3733",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

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Porjesz, B, Almasy, L, Edenberg, HJ, Wang, K, Chorlian, DB, Foroud, T, Goate, A, Rice, JP, O'Connor, SJ, Rohrbaugh, J, Kuperman, S, Bauer, LO, Crowe, RR, Schuckit, MA, Hesselbrock, V, Conneally, PM, Tischfield, JA, Li, TK, Reich, T & Begleiter, H 2002, 'Linkage disequilibrium between the beta frequency of the human EEG and a GABA_A receptor gene locus', Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 6, pp. 3729-3733. https://doi.org/10.1073/pnas.052716399

TY - JOUR

T1 - Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

AU - Porjesz, Bernice

AU - Almasy, Laura

AU - Edenberg, Howard J.

AU - Wang, Kongming

AU - Chorlian, David B.

AU - Foroud, Tatiana

AU - Goate, Alison

AU - Rice, John P.

AU - O'Connor, Sean J.

AU - Rohrbaugh, John

AU - Kuperman, Samuel

AU - Bauer, Lance O.

AU - Crowe, Raymond R.

AU - Schuckit, Marc A.

AU - Hesselbrock, Victor

AU - Conneally, P. Michael

AU - Tischfield, Jay A.

AU - Li, Ting Kai

AU - Reich, Theodore

AU - Begleiter, Henri

PY - 2002/3/19

Y1 - 2002/3/19

N2 - Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABAA) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABAA receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.

AB - Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABAA) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABAA receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.

UR - https://www.scopus.com/pages/publications/18344368607

U2 - 10.1073/pnas.052716399

DO - 10.1073/pnas.052716399

M3 - Article

C2 - 11891318

AN - SCOPUS:18344368607

SN - 0027-8424

VL - 99

SP - 3729

EP - 3733

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 6

ER -

Linkage disequilibrium between the beta frequency of the human EEG and a GABA_A receptor gene locus

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