Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

Bernice Porjesz; Laura Almasy; Howard J. Edenberg; Kongming Wang; David B. Chorlian; Tatiana Foroud; Alison Goate; John P. Rice; Sean J. O'Connor; John Rohrbaugh; Samuel Kuperman; Lance O. Bauer; Raymond R. Crowe; Marc A. Schuckit; Victor Hesselbrock; P. Michael Conneally; Jay A. Tischfield; Ting Kai Li; Theodore Reich; Henri Begleiter

doi:10.1073/pnas.052716399

Linkage disequilibrium between the beta frequency of the human EEG and a GABA_A receptor gene locus

Bernice Porjesz, Laura Almasy, Howard J. Edenberg, Kongming Wang, David B. Chorlian, Tatiana Foroud, Alison Goate, John P. Rice, Sean J. O'Connor, John Rohrbaugh, Samuel Kuperman, Lance O. Bauer, Raymond R. Crowe, Marc A. Schuckit, Victor Hesselbrock, P. Michael Conneally, Jay A. Tischfield, Ting Kai Li, Theodore Reich, Henri Begleiter

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269 Scopus citations

Abstract

Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABA_A) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABA_A receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.

Original language	English
Pages (from-to)	3729-3733
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	99
Issue number	6
DOIs	https://doi.org/10.1073/pnas.052716399
State	Published - Mar 19 2002

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Porjesz, B., Almasy, L., Edenberg, H. J., Wang, K., Chorlian, D. B., Foroud, T., Goate, A., Rice, J. P., O'Connor, S. J., Rohrbaugh, J., Kuperman, S., Bauer, L. O., Crowe, R. R., Schuckit, M. A., Hesselbrock, V., Conneally, P. M., Tischfield, J. A., Li, T. K., Reich, T., & Begleiter, H. (2002). Linkage disequilibrium between the beta frequency of the human EEG and a GABA_A receptor gene locus. Proceedings of the National Academy of Sciences of the United States of America, 99(6), 3729-3733. https://doi.org/10.1073/pnas.052716399

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title = "Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus",

abstract = "Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABAA) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABAA receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.",

author = "Bernice Porjesz and Laura Almasy and Edenberg, {Howard J.} and Kongming Wang and Chorlian, {David B.} and Tatiana Foroud and Alison Goate and Rice, {John P.} and O'Connor, {Sean J.} and John Rohrbaugh and Samuel Kuperman and Bauer, {Lance O.} and Crowe, {Raymond R.} and Schuckit, {Marc A.} and Victor Hesselbrock and Conneally, {P. Michael} and Tischfield, {Jay A.} and Li, {Ting Kai} and Theodore Reich and Henri Begleiter",

year = "2002",

month = mar,

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doi = "10.1073/pnas.052716399",

language = "English",

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Porjesz, B, Almasy, L, Edenberg, HJ, Wang, K, Chorlian, DB, Foroud, T, Goate, A, Rice, JP, O'Connor, SJ, Rohrbaugh, J, Kuperman, S, Bauer, LO, Crowe, RR, Schuckit, MA, Hesselbrock, V, Conneally, PM, Tischfield, JA, Li, TK, Reich, T & Begleiter, H 2002, 'Linkage disequilibrium between the beta frequency of the human EEG and a GABA_A receptor gene locus', Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 6, pp. 3729-3733. https://doi.org/10.1073/pnas.052716399

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T1 - Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus

AU - Porjesz, Bernice

AU - Almasy, Laura

AU - Edenberg, Howard J.

AU - Wang, Kongming

AU - Chorlian, David B.

AU - Foroud, Tatiana

AU - Goate, Alison

AU - Rice, John P.

AU - O'Connor, Sean J.

AU - Rohrbaugh, John

AU - Kuperman, Samuel

AU - Bauer, Lance O.

AU - Crowe, Raymond R.

AU - Schuckit, Marc A.

AU - Hesselbrock, Victor

AU - Conneally, P. Michael

AU - Tischfield, Jay A.

AU - Li, Ting Kai

AU - Reich, Theodore

AU - Begleiter, Henri

PY - 2002/3/19

Y1 - 2002/3/19

N2 - Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABAA) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABAA receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.

AB - Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by γ-aminobutyric acid type A (GABAA) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABAA receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.

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AN - SCOPUS:18344368607

SN - 0027-8424

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 6

ER -

Linkage disequilibrium between the beta frequency of the human EEG and a GABA_A receptor gene locus

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