@article{1617cbea5631442aa8852dbea2988c11,
title = "Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: Implications for human brain dynamics and cognition",
abstract = "Event-related oscillations (ERO) offer an alternative theoretical and methodological approach to the analysis of event-related EEG responses. The P300 event-related potential (ERP) is elicited through the superposition of the delta (1-3 Hz) and theta (3-7 Hz) band oscillatory responses. The cholinergic neurotransmitter system has a key function in modulating excitatory post-synaptic potentials caused by glutamate, and therefore influences P300 generation and the underlying oscillatory responses. Here we report significant linkage and linkage disequilibrium between target case frontal theta band, visual evoked brain oscillations and a single nucleotide polymorphism (SNP) from the cholinergic muscarinic receptor gene (CHRM2) on chromosome 7. We also demonstrate significant linkage disequilibrium between CHRM2 SNPs and target case parietal delta band visual evoked oscillations (LD P<0.001). These findings were not observed for the equivalent non-target case data, suggesting a role for the CHRM2 gene in higher cognitive processing in humans.",
keywords = "CHRM2, Cholinergic muscarinic receptors, Delta, Event-related oscillations, Linkage disequilibrium, P300, Theta",
author = "Jones, {Kevin A.} and Bernice Porjesz and Laura Almasy and Laura Bierut and Alison Goate and Wang, {Jen C.} and Dick, {Danielle M.} and Anthony Hinrichs and Jennifer Kwon and Rice, {John P.} and John Rohrbaugh and Heather Stock and William Wu and Bauer, {Lance O.} and Chorlian, {David B.} and Crowe, {Raymond R.} and Edenberg, {Howard J.} and Tatiana Foroud and Victor Hesselbrock and Samuel Kuperman and John Nurnberger and O'Connor, {Sean J.} and Schuckit, {Marc A.} and Stimus, {Arthur T.} and Tischfield, {Jay A.} and Theodore Reich and Henri Begleiter",
note = "Funding Information: The Collaborative Study on the Genetics of Alcoholism (COGA) (Principal Investigator: H. Begleiter; Co-Principal Investigators: L. Bierut, H. Edenberg, V. Hesselbrock, Bernice Porjesz) includes nine different centers where data collection, analysis, and storage take place. The nine sites and Principal Investigators and Co-Investigators are: University of Connecticut (V. Hesselbrock); Indiana University (H. Edenberg, J. Nurnberger Jr., P.M. Conneally, T. Foroud); University of Iowa (R. Crowe, S. Kuperman); SUNY HSCB (B. Porjesz, H. Begleiter); Washington University in St. Louis (L. Bierut, J. Rice, A. Goate); University of California at San Diego (M. Schuckit); Howard University (R. Taylor); Rutgers University (J. Tischfield); Southwest Foundation (L. Almasy). Lisa Neuhold serves as the NIAAA Staff Collaborator. This national collaborative study is supported by the NIH Grant U10AA08403 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). ",
year = "2004",
month = jul,
doi = "10.1016/j.ijpsycho.2004.02.004",
language = "English",
volume = "53",
pages = "75--90",
journal = "International Journal of Psychophysiology",
issn = "0167-8760",
number = "2",
}