Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the old order Amish

D. L. Pauls; J. Ott; S. M. Paul; C. R. Allen; C. S.J. Fann; J. P. Carulli; K. M. Falls; C. A. Bouthillier; T. C. Gravius; T. P. Keith; J. A. Egeland; E. I. Ginns

Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the old order Amish

D. L. Pauls, J. Ott, S. M. Paul, C. R. Allen, C. S.J. Fann, J. P. Carulli, K. M. Falls, C. A. Bouthillier, T. C. Gravius, T. P. Keith, J. A. Egeland, E. I. Ginns

Washington University School of Medicine

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar 1 (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP l individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population.

Original language	English
Pages (from-to)	636-643
Number of pages	8
Journal	American journal of human genetics
Volume	57
Issue number	3
State	Published - Sep 1995

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Pauls, D. L., Ott, J., Paul, S. M., Allen, C. R., Fann, C. S. J., Carulli, J. P., Falls, K. M., Bouthillier, C. A., Gravius, T. C., Keith, T. P., Egeland, J. A., & Ginns, E. I. (1995). Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the old order Amish. American journal of human genetics, 57(3), 636-643.

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title = "Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the old order Amish",

abstract = "Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar 1 (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP l individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population.",

author = "Pauls, {D. L.} and J. Ott and Paul, {S. M.} and Allen, {C. R.} and Fann, {C. S.J.} and Carulli, {J. P.} and Falls, {K. M.} and Bouthillier, {C. A.} and Gravius, {T. C.} and Keith, {T. P.} and Egeland, {J. A.} and Ginns, {E. I.}",

year = "1995",

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T1 - Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the old order Amish

AU - Pauls, D. L.

AU - Ott, J.

AU - Paul, S. M.

AU - Allen, C. R.

AU - Fann, C. S.J.

AU - Carulli, J. P.

AU - Falls, K. M.

AU - Bouthillier, C. A.

AU - Gravius, T. C.

AU - Keith, T. P.

AU - Egeland, J. A.

AU - Ginns, E. I.

PY - 1995/9

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N2 - Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar 1 (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP l individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population.

AB - Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar 1 (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP l individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population.

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Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the old order Amish

Abstract

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