Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar 1 (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP l individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population.
|Number of pages||8|
|Journal||American journal of human genetics|
|State||Published - 1995|