LINC00355 regulates p27KIP expression by binding to MENIN to induce proliferation in late-stage relapse breast cancer

Abdallah M. Eteleeb; Prasanth K. Thunuguntla; Kyla Z. Gelev; Cynthia Y. Tang; Emily B. Rozycki; Alexander Miller; Jonathan T. Lei; Reyka G. Jayasinghe; Ha X. Dang; Nicole M. White; Jorge S. Reis-Filho; Elaine R. Mardis; Matthew J. Ellis; Li Ding; Jessica M. Silva-Fisher; Christopher A. Maher

doi:10.1038/s41523-022-00412-2

LINC00355 regulates p27^KIP expression by binding to MENIN to induce proliferation in late-stage relapse breast cancer

Abdallah M. Eteleeb, Prasanth K. Thunuguntla, Kyla Z. Gelev, Cynthia Y. Tang, Emily B. Rozycki, Alexander Miller, Jonathan T. Lei, Reyka G. Jayasinghe, Ha X. Dang, Nicole M. White, Jorge S. Reis-Filho, Elaine R. Mardis, Matthew J. Ellis, Li Ding, Jessica M. Silva-Fisher, Christopher A. Maher

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Abstract

Late-stage relapse (LSR) in patients with breast cancer (BC) occurs more than five years and up to 10 years after initial treatment and has less than 30% 5-year relative survival rate. Long non-coding RNAs (lncRNAs) play important roles in BC yet have not been studied in LSR BC. Here, we identify 1127 lncRNAs differentially expressed in LSR BC via transcriptome sequencing and analysis of 72 early-stage and 24 LSR BC patient tumors. Decreasing expression of the most up-regulated lncRNA, LINC00355, in BC and MCF7 long-term estrogen deprived cell lines decreases cellular invasion and proliferation. Subsequent mechanistic studies show that LINC00355 binds to MENIN and changes occupancy at the CDKN1B promoter to decrease p27^Kip. In summary, this is a key study discovering lncRNAs in LSR BC and LINC00355 association with epigenetic regulation and proliferation in BC.

Original language	English
Article number	49
Journal	npj Breast Cancer
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41523-022-00412-2
State	Published - Dec 2022

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Eteleeb, A. M., Thunuguntla, P. K., Gelev, K. Z., Tang, C. Y., Rozycki, E. B., Miller, A., Lei, J. T., Jayasinghe, R. G., Dang, H. X., White, N. M., Reis-Filho, J. S., Mardis, E. R., Ellis, M. J., Ding, L., Silva-Fisher, J. M., & Maher, C. A. (2022). LINC00355 regulates p27^KIP expression by binding to MENIN to induce proliferation in late-stage relapse breast cancer. npj Breast Cancer, 8(1), Article 49. https://doi.org/10.1038/s41523-022-00412-2

@article{0a76a3d1b1a64fc5b8138a34096997dc,

title = "LINC00355 regulates p27KIP expression by binding to MENIN to induce proliferation in late-stage relapse breast cancer",

abstract = "Late-stage relapse (LSR) in patients with breast cancer (BC) occurs more than five years and up to 10 years after initial treatment and has less than 30% 5-year relative survival rate. Long non-coding RNAs (lncRNAs) play important roles in BC yet have not been studied in LSR BC. Here, we identify 1127 lncRNAs differentially expressed in LSR BC via transcriptome sequencing and analysis of 72 early-stage and 24 LSR BC patient tumors. Decreasing expression of the most up-regulated lncRNA, LINC00355, in BC and MCF7 long-term estrogen deprived cell lines decreases cellular invasion and proliferation. Subsequent mechanistic studies show that LINC00355 binds to MENIN and changes occupancy at the CDKN1B promoter to decrease p27Kip. In summary, this is a key study discovering lncRNAs in LSR BC and LINC00355 association with epigenetic regulation and proliferation in BC.",

author = "Eteleeb, {Abdallah M.} and Thunuguntla, {Prasanth K.} and Gelev, {Kyla Z.} and Tang, {Cynthia Y.} and Rozycki, {Emily B.} and Alexander Miller and Lei, {Jonathan T.} and Jayasinghe, {Reyka G.} and Dang, {Ha X.} and White, {Nicole M.} and Reis-Filho, {Jorge S.} and Mardis, {Elaine R.} and Ellis, {Matthew J.} and Li Ding and Silva-Fisher, {Jessica M.} and Maher, {Christopher A.}",

note = "Publisher Copyright: {\textcopyright} 2022, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.",

year = "2022",

month = dec,

doi = "10.1038/s41523-022-00412-2",

language = "English",

volume = "8",

journal = "npj Breast Cancer",

issn = "2374-4677",

number = "1",

}

Eteleeb, AM, Thunuguntla, PK, Gelev, KZ, Tang, CY, Rozycki, EB, Miller, A, Lei, JT, Jayasinghe, RG, Dang, HX, White, NM, Reis-Filho, JS, Mardis, ER, Ellis, MJ, Ding, L , Silva-Fisher, JM & Maher, CA 2022, 'LINC00355 regulates p27^KIP expression by binding to MENIN to induce proliferation in late-stage relapse breast cancer', npj Breast Cancer, vol. 8, no. 1, 49. https://doi.org/10.1038/s41523-022-00412-2

TY - JOUR

T1 - LINC00355 regulates p27KIP expression by binding to MENIN to induce proliferation in late-stage relapse breast cancer

AU - Eteleeb, Abdallah M.

AU - Thunuguntla, Prasanth K.

AU - Gelev, Kyla Z.

AU - Tang, Cynthia Y.

AU - Rozycki, Emily B.

AU - Miller, Alexander

AU - Lei, Jonathan T.

AU - Jayasinghe, Reyka G.

AU - Dang, Ha X.

AU - White, Nicole M.

AU - Reis-Filho, Jorge S.

AU - Mardis, Elaine R.

AU - Ellis, Matthew J.

AU - Ding, Li

AU - Silva-Fisher, Jessica M.

AU - Maher, Christopher A.

PY - 2022/12

Y1 - 2022/12

N2 - Late-stage relapse (LSR) in patients with breast cancer (BC) occurs more than five years and up to 10 years after initial treatment and has less than 30% 5-year relative survival rate. Long non-coding RNAs (lncRNAs) play important roles in BC yet have not been studied in LSR BC. Here, we identify 1127 lncRNAs differentially expressed in LSR BC via transcriptome sequencing and analysis of 72 early-stage and 24 LSR BC patient tumors. Decreasing expression of the most up-regulated lncRNA, LINC00355, in BC and MCF7 long-term estrogen deprived cell lines decreases cellular invasion and proliferation. Subsequent mechanistic studies show that LINC00355 binds to MENIN and changes occupancy at the CDKN1B promoter to decrease p27Kip. In summary, this is a key study discovering lncRNAs in LSR BC and LINC00355 association with epigenetic regulation and proliferation in BC.

AB - Late-stage relapse (LSR) in patients with breast cancer (BC) occurs more than five years and up to 10 years after initial treatment and has less than 30% 5-year relative survival rate. Long non-coding RNAs (lncRNAs) play important roles in BC yet have not been studied in LSR BC. Here, we identify 1127 lncRNAs differentially expressed in LSR BC via transcriptome sequencing and analysis of 72 early-stage and 24 LSR BC patient tumors. Decreasing expression of the most up-regulated lncRNA, LINC00355, in BC and MCF7 long-term estrogen deprived cell lines decreases cellular invasion and proliferation. Subsequent mechanistic studies show that LINC00355 binds to MENIN and changes occupancy at the CDKN1B promoter to decrease p27Kip. In summary, this is a key study discovering lncRNAs in LSR BC and LINC00355 association with epigenetic regulation and proliferation in BC.

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U2 - 10.1038/s41523-022-00412-2

DO - 10.1038/s41523-022-00412-2

M3 - Article

C2 - 35418131

AN - SCOPUS:85128230136

SN - 2374-4677

VL - 8

JO - npj Breast Cancer

JF - npj Breast Cancer

IS - 1

M1 - 49

ER -

LINC00355 regulates p27^KIP expression by binding to MENIN to induce proliferation in late-stage relapse breast cancer

Abstract

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