TY - JOUR
T1 - Limited sequence variation in human T-lymphotropic virus type 1 isolates from North American and African patients
AU - Paine, Elizabeth
AU - Garcia, Juan
AU - Philpott, Timothy C.
AU - Shaw, George
AU - Ratner, Lee
N1 - Funding Information:
We thank Wen Hu for assistance with subclonlng HTLV-I-SP env and HTLV-I-CH, Beatrice Hahn for assistance in obtaining HTLV-I- CH, Flossie Wong-Staal and Robert Gallofor support during the cloning of HTLV-I-CH, and Jason Kimata for critical review of the manuscript. This work was supported by PHS Grant Al24745 and Contract DAMD17-87-7102. L.R. is an American Cancer Society Research Professor.
PY - 1991/5
Y1 - 1991/5
N2 - Nucleotide sequences were determined from the env genes of three HTLV-I clones derived from two North American patients and one African patient with adult T-cell leukemia/lymphoma (ATLL region, between env and the 3′LTR, were determined from one of these isolates. These data were compared to sequences derived from HTLV-I isolates of two Japanese ATLL patients, a Japanese patient with HTLV-I-associated myelopathy or tropical spastic paraparesis (HAM/TSP) and a Caribbean ATLL patient. Nucleotide sequence variation was found to be <6% in coding and noncoding regions. Predicted amino acid sequences varied between 0.6 and 1.8% in the envelope, 0-3.7% in rex, 0.8-2.5% in the tax gene product, and 3-14.0% in the pX-I open reading frame. Comparisons of the predicted amino acid sequences of the surface envelope protein (SU-gp46) suggest that the variation between isolates of different geographical origins is greater than that between isolates obtained from the same region of the world.
AB - Nucleotide sequences were determined from the env genes of three HTLV-I clones derived from two North American patients and one African patient with adult T-cell leukemia/lymphoma (ATLL region, between env and the 3′LTR, were determined from one of these isolates. These data were compared to sequences derived from HTLV-I isolates of two Japanese ATLL patients, a Japanese patient with HTLV-I-associated myelopathy or tropical spastic paraparesis (HAM/TSP) and a Caribbean ATLL patient. Nucleotide sequence variation was found to be <6% in coding and noncoding regions. Predicted amino acid sequences varied between 0.6 and 1.8% in the envelope, 0-3.7% in rex, 0.8-2.5% in the tax gene product, and 3-14.0% in the pX-I open reading frame. Comparisons of the predicted amino acid sequences of the surface envelope protein (SU-gp46) suggest that the variation between isolates of different geographical origins is greater than that between isolates obtained from the same region of the world.
UR - http://www.scopus.com/inward/record.url?scp=0025796868&partnerID=8YFLogxK
U2 - 10.1016/0042-6822(91)90654-T
DO - 10.1016/0042-6822(91)90654-T
M3 - Article
C2 - 2024459
AN - SCOPUS:0025796868
SN - 0042-6822
VL - 182
SP - 111
EP - 123
JO - Virology
JF - Virology
IS - 1
ER -