Limitations on detection of gradients of diffusible chemicals by axons

J. S. Urbach; Geoffrey J. Goodhill

doi:10.1016/S0925-2312(99)00086-7

Limitations on detection of gradients of diffusible chemicals by axons

J. S. Urbach, Geoffrey J. Goodhill

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This paper applies a simple analysis of the statistical noise inherent in sensing concentrations of diffusible chemical factors to the problem of guidance of developing axons. We show that growth cones may be able to detect chemical changes of 0.5% across their width, and that guidance by a gradient is limited to distances below about 1 cm, even for a gradient of ideal shape.

Original language	English
Pages (from-to)	39-43
Number of pages	5
Journal	Neurocomputing
Volume	26-27
DOIs	https://doi.org/10.1016/S0925-2312(99)00086-7
State	Published - Jun 1999

Keywords

Axon guidance
Chemotaxis
Gradients
Growth cone

Access to Document

10.1016/S0925-2312(99)00086-7

Cite this

@article{678818e7ffb34941a36198baf533b31b,

title = "Limitations on detection of gradients of diffusible chemicals by axons",

abstract = "This paper applies a simple analysis of the statistical noise inherent in sensing concentrations of diffusible chemical factors to the problem of guidance of developing axons. We show that growth cones may be able to detect chemical changes of 0.5\% across their width, and that guidance by a gradient is limited to distances below about 1 cm, even for a gradient of ideal shape.",

keywords = "Axon guidance, Chemotaxis, Gradients, Growth cone",

author = "Urbach, \{J. S.\} and Goodhill, \{Geoffrey J.\}",

note = "Funding Information: This work was partly supported by DOD grant DAMD17-93-V-3018 (GJG), and by the Alfred P. Sloan Foundation (JSU). ",

year = "1999",

month = jun,

doi = "10.1016/S0925-2312(99)00086-7",

language = "English",

volume = "26-27",

pages = "39--43",

journal = "Neurocomputing",

issn = "0925-2312",

}

TY - JOUR

T1 - Limitations on detection of gradients of diffusible chemicals by axons

AU - Urbach, J. S.

AU - Goodhill, Geoffrey J.

N1 - Funding Information: This work was partly supported by DOD grant DAMD17-93-V-3018 (GJG), and by the Alfred P. Sloan Foundation (JSU).

PY - 1999/6

Y1 - 1999/6

N2 - This paper applies a simple analysis of the statistical noise inherent in sensing concentrations of diffusible chemical factors to the problem of guidance of developing axons. We show that growth cones may be able to detect chemical changes of 0.5% across their width, and that guidance by a gradient is limited to distances below about 1 cm, even for a gradient of ideal shape.

AB - This paper applies a simple analysis of the statistical noise inherent in sensing concentrations of diffusible chemical factors to the problem of guidance of developing axons. We show that growth cones may be able to detect chemical changes of 0.5% across their width, and that guidance by a gradient is limited to distances below about 1 cm, even for a gradient of ideal shape.

KW - Axon guidance

KW - Chemotaxis

KW - Gradients

KW - Growth cone

UR - https://www.scopus.com/pages/publications/17144443624

U2 - 10.1016/S0925-2312(99)00086-7

DO - 10.1016/S0925-2312(99)00086-7

M3 - Article

AN - SCOPUS:17144443624

SN - 0925-2312

VL - 26-27

SP - 39

EP - 43

JO - Neurocomputing

JF - Neurocomputing

ER -

Limitations on detection of gradients of diffusible chemicals by axons

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this