Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance imaging of vascular targets

Dipanjan Pan, Shelton D. Caruthers, Grace Hu, Angana Senpan, Mike J. Scott, Patrick J. Gaffney, Samuel A. Wickline, Gregory M. Lanza

Research output: Contribution to journalArticlepeer-review

154 Scopus citations

Abstract

Although gadolinium has been the dominant paramagnetic metal for MR paramagnetic contrast agents, the recent association of this lanthanide with nephrogenic systemic fibrosis, an untreatable disease, has spawned renewed interest in alternative metals for MR molecular imaging. We have developed a self-assembled, manganese(III)-labeled nanobialys (1), a toroidal-shaped MR theranostic nanoparticle. In this report, Mn(III) nanobialys are characterized as MR molecular imaging agents for targeted detection of fibrin, a major biochemical feature of thrombus. A complementary ability of nanobialys to incorporate chemotherapeutic compounds with greater than 98% efficiency and to retain more than 80% of these drugs after infinite sink dissolution, point to the theranostic potential of this platform technology.

Original languageEnglish
Pages (from-to)9186-9187
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number29
DOIs
StatePublished - Jul 23 2008

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