TY - JOUR
T1 - Lifetime psychiatric comorbidity of alcohol dependence and bulimia nervosa in women
AU - Duncan, Alexis E.
AU - Neuman, Rosalind J.
AU - Kramer, John R.
AU - Kuperman, Samuel
AU - Hesselbrock, Victor M.
AU - Bucholz, Kathleen Keenan
N1 - Funding Information:
The Collaborative Study on the Genetics of Alcoholism (Begleiter, H., State University of New York, Health Sciences Center at Brooklyn [PI]; Bierut, L., Washington University, Edenberg, H., Indiana University, Hesselbrock, V., University of Connecticut, Porjesz, B., State University of New York, Brooklyn [Co-PIs]) includes nine different centers where data collection, analysis, and/or storage take place. The nine sites and PIs and Co-PIs include: University of Connecticut (Hesselbrock, V.); Indiana University (Nurnberger Jr., J., Conneally, P.M., Edenberg, H., Foroud, T.); University of Iowa (Crowe, R., Kuperman, S.); State University of New York, Brooklyn (Porjesz, B., Begleiter, H.); Washington University (Bierut, L., Goate, A., Rice, J.); University of California, San Diego (Schuckit, M.); Howard University (Taylor, R.); Rutgers University (Tischfield, J.); Southwest Foundation (Almasy, L.), Zhaoxia Ren, NIAAA Staff Collaborator. In memory of Theodore Reich, MD, Co-Principal Investigator of COGA since its inception and one of the founders of modern psychiatric genetics, we acknowledge his immeasurable and fundamental scientific contributions to COGA and the field. This national collaborative study is supported by the NIH Grant U10AA08403 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). This work was also supported by AA12640, DA14363 and AA11998.
PY - 2006/9/1
Y1 - 2006/9/1
N2 - Previous work from our group revealed two groups of women with bulimia nervosa (BN), one with, and one without alcohol dependence (AD). The current study sought to determine whether women with lifetime BN and AD (BN+AD+) were more similar to women with BN and no AD (BN+AD-) or to women with AD and no BN (BN-AD+) in terms of lifetime psychiatric comorbidity and psychological functioning. Data on BN and AD from 407 female relatives in a family study of alcoholism were used to create three mutually exclusive groups: BN+AD+ (n = 30), BN+AD- (n = 55), and BN-AD+ (n = 322). Bivariate analyses revealed fewer differences between BN+AD+ and BN-AD+ women than between BN+AD+ and BN+AD- women. BN+AD+ women were more likely than BN+AD- women to have drug dependence, conduct disorder, and suicidality, and were more likely to have major depression, lower GAF scores, and to engage in unsafe sex than both BN+AD- and BN-AD+ women. After adjusting for other psychopathology and demographic variables, BN+AD+ women were more likely than BN+AD- women to have major depression, drug dependence, and tobacco dependence and more likely than BN-AD+ women to have major depression and obsessive-compulsive disorder. These results suggest that BN+AD+ women exhibit more severe psychopathology than either BN+AD- or BN-AD+ women and may represent a distinct subgroup within bulimia nervosa or alcohol dependence.
AB - Previous work from our group revealed two groups of women with bulimia nervosa (BN), one with, and one without alcohol dependence (AD). The current study sought to determine whether women with lifetime BN and AD (BN+AD+) were more similar to women with BN and no AD (BN+AD-) or to women with AD and no BN (BN-AD+) in terms of lifetime psychiatric comorbidity and psychological functioning. Data on BN and AD from 407 female relatives in a family study of alcoholism were used to create three mutually exclusive groups: BN+AD+ (n = 30), BN+AD- (n = 55), and BN-AD+ (n = 322). Bivariate analyses revealed fewer differences between BN+AD+ and BN-AD+ women than between BN+AD+ and BN+AD- women. BN+AD+ women were more likely than BN+AD- women to have drug dependence, conduct disorder, and suicidality, and were more likely to have major depression, lower GAF scores, and to engage in unsafe sex than both BN+AD- and BN-AD+ women. After adjusting for other psychopathology and demographic variables, BN+AD+ women were more likely than BN+AD- women to have major depression, drug dependence, and tobacco dependence and more likely than BN-AD+ women to have major depression and obsessive-compulsive disorder. These results suggest that BN+AD+ women exhibit more severe psychopathology than either BN+AD- or BN-AD+ women and may represent a distinct subgroup within bulimia nervosa or alcohol dependence.
KW - Alcohol dependence
KW - Bulimia nervosa
KW - COGA
KW - Comorbidity
UR - http://www.scopus.com/inward/record.url?scp=33746291910&partnerID=8YFLogxK
U2 - 10.1016/j.drugalcdep.2006.01.005
DO - 10.1016/j.drugalcdep.2006.01.005
M3 - Article
C2 - 16455211
AN - SCOPUS:33746291910
SN - 0376-8716
VL - 84
SP - 122
EP - 132
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
IS - 1
ER -