Library-driven approach for fast implementation of the voxel spread function to correct magnetic field inhomogeneity artifacts for gradient-echo sequences

Purpose: Previously developed Voxel Spread Function (VSF) method (Yablonskiy, et al, MRM, 2013;70:1283) provides solution to correct artifacts induced by macroscopic magnetic field inhomogeneity in the images obtained by multi-Gradient-Recalled-Echo (mGRE) techniques. The goal of this study was to develop a library-driven approach for fast VSF implementation. Methods: The VSF approach describes the contribution of the magnetic field inhomogeneity effects on the mGRE signal decay in terms of the F-function calculated from mGRE phase and magnitude images. A pre-calculated library accounting for a variety of background field gradients caused by magnetic field inhomogeneity was used herein to speed up the calculation of F-function. Quantitative R2* maps from the mGRE data collected from two healthy volunteers were generated using the library as validation. Results: As compared with direct calculation of the F-function based on a voxel-wise approach, the new library-driven method substantially reduces computational time from several hours to few minutes, while, at the same time, providing similar accuracy of R2* mapping. Conclusion: The new procedure proposed in this study provides a fast post-processing algorithm that can be incorporated in the quantitative analysis of mGRE data to account for background field inhomogeneity artifacts, thus can facilitate the applications of mGRE-based quantitative techniques in clinical practices.