Abstract
Highly regioselective vinylogous aldol additions of silyl dienol ethers derived from simple α,β-unsaturated ketones are described. The catalyst system of silicon tetrachloride activated by chiral bisphosphoramide (R,R)-1 effectively promotes the addition of both γ-substituted and unsubstituted silyl dienol ethers to a variety of aldehydes with exclusive γ-regioselectivity and good to excellent diastereo- and enantioselectivity.
| Original language | English |
|---|---|
| Pages (from-to) | 2411-2416 |
| Number of pages | 6 |
| Journal | Synlett |
| Issue number | 13 |
| DOIs | |
| State | Published - Nov 3 2004 |
Keywords
- Asymmetric catalysis
- Ketones
- Lewis base
- Regioselectivity
- Vinylogous aldol reactions