Level of skeletal muscle glucose transporter protein correlates with insulin-stimulated whole body glucose disposal in man

L. I. Koranyi, R. E. Bourey, H. Vuorinen-Markkola, V. A. Koivisto, M. Mueckler, M. A. Permutt, H. Yki-Järvinen

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

The content of GLUT4 glucose transporter mRNA and protein were measured in samples of the vastus lateralis muscle of normal volunteers subjected to a 4-h hyperinsulinaemic, euglycaemic clamp. Plasma glucose concentration was clamped at 5.3±0.1 mmol/l, and serum insulin concentration was maintained at 740±5 pmol/l. Whole body glucose uptake averaged 38.3±2.2 μmol · kg-1 · min-1, 62% of this being due to disposal via non-oxidative pathways. A significant correlation existed between basal levels of GLUT4 protein and the rate of whole body glucose disposal (r=0.77, p<0.02) and non-oxidative glucose disposal (r=0.80, p<0.02). There was no correlation between GLUT4 protein content and oxidative glucose disposal (r=0.08, NS). These observations are consistent with an important role for skeletal muscle GLUT4 protein in whole body glucose disposal.

Original languageEnglish
Pages (from-to)763-765
Number of pages3
JournalDiabetologia
Volume34
Issue number10
DOIs
StatePublished - Oct 1991

Keywords

  • GLUT4
  • Glucose transport
  • euglycaemic clamp
  • insulin
  • muscle

Fingerprint

Dive into the research topics of 'Level of skeletal muscle glucose transporter protein correlates with insulin-stimulated whole body glucose disposal in man'. Together they form a unique fingerprint.

Cite this