Leukotriene B4 in inflammatory bowel disease

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Abstract

Leukotriene B4 is an inflammatory mediator produced by metabolism of arachidonic acid through the 5-lipoxygenase pathway in neutrophils, macrophages and mast cells. The major biological effect of leukotriene B4 is the activation of circulating neutrophils to bind to the vascular endothelium and migrate into inflamed tissues. There are markedly elevated levels of leukotriene B4 an inflammatory bowel disease and there is considerable evidence that it is an important neutrophil activator in this disease. Preliminary studies suggest that inhibition of leukotriene B4 synthesis may be therapeutic in inflammatory bowel disease.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalCanadian Journal of Gastroenterology
Volume7
Issue number2
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

Keywords

  • 5-Lipoxygenase
  • Arachidonic acid
  • Leukotriene B4
  • Neutrophil
  • Ulcerative colitis

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