TY - JOUR
T1 - Leptomeningeal metastasis as initial manifestation of signet ring colorectal adenocarcinoma
T2 - A case report with review of literature
AU - Assi, Rita
AU - Hamieh, Lana
AU - Mukherji, Deborah
AU - Haydar, Ali
AU - Temraz, Sally
AU - El-Dika, Imane
AU - Shamseddine, Ali
N1 - Publisher Copyright:
© Journal of Gastrointestinal Oncology. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Leptomeningeal carcinomatosis (LMC) is an exceedingly rare event especially as a first manifestation of an occult primary colorectal cancer and even when there is a known history of malignancy. Sensorineural hearing loss is by itself an unusual isolated presentation of LMC with unsolved pathophysiology in this setting. In this paper, we report such a case and review the literature for similar cases, focusing on postulated mechanisms of spread. In view of the poor prognosis they carry, we highly recommend that physicians be aware of the risk of rare metastasis from colorectal adenocarcinoma in order to establish an early confirmative diagnosis.
AB - Leptomeningeal carcinomatosis (LMC) is an exceedingly rare event especially as a first manifestation of an occult primary colorectal cancer and even when there is a known history of malignancy. Sensorineural hearing loss is by itself an unusual isolated presentation of LMC with unsolved pathophysiology in this setting. In this paper, we report such a case and review the literature for similar cases, focusing on postulated mechanisms of spread. In view of the poor prognosis they carry, we highly recommend that physicians be aware of the risk of rare metastasis from colorectal adenocarcinoma in order to establish an early confirmative diagnosis.
KW - Colon cancer
KW - Hearing loss
KW - Leptomeningeal carcinomatosis (LMC)
KW - Signet ring
UR - http://www.scopus.com/inward/record.url?scp=84995771980&partnerID=8YFLogxK
U2 - 10.3978/j.issn.2078-6891.2015.087
DO - 10.3978/j.issn.2078-6891.2015.087
M3 - Article
AN - SCOPUS:84995771980
SN - 2078-6891
VL - 6
SP - E89-E101
JO - Journal of Gastrointestinal Oncology
JF - Journal of Gastrointestinal Oncology
IS - 6
ER -