Leptin monotherapy rescues spermatogenesis in male akita type 1 diabetic mice

Erica L. Schoeller, Maggie Chi, Andrea Drury, Ashley Bertschinger, Prabagaran Esakky, Kelle H. Moley

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Type 1 diabetes is associated with subfertility in humans. The current treatment for type 1 diabetes, insulin monotherapy, is suboptimal to fully stabilize glycemia, potentially leading to this subfer-tility. Recent work has demonstrated that treatment with the energy-regulating hormone leptin, alone or in combination with insulin, can more effectively control glycemia in mouse models of type 1 diabetes. Here, we sought to determine whether the fertility defects in a type 1 diabetic mouse model, the Akita mouse, can be rescued with leptin monotherapy in the absence of any exogenous insulin. Akita homozygous mice treated with leptin alone had a larger total body size, testes, and seminal vesicles than their untreated siblings. Leptin treatment prevented testicular degeneration and rescued sperm motility to wild-type levels. Furthermore, sperm obtained from leptin-treated mice could successfully fertilize ooctyes in vitro. Despite completely rescuing spermatogenesis, the critical reproductive hormones LH and testosterone were only modestly higher than in untreated mice, indicatingthat a minimum threshold of these hormones must be metto maintain spermatogenesis. Cumulatively, these findings implicate the importance of leptin in maintaining fertility and support the use of leptin therapy in the treatment of type 1 diabetes.

Original languageEnglish
Pages (from-to)2781-2786
Number of pages6
JournalEndocrinology
Volume155
Issue number8
DOIs
StatePublished - Aug 2014

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    Schoeller, E. L., Chi, M., Drury, A., Bertschinger, A., Esakky, P., & Moley, K. H. (2014). Leptin monotherapy rescues spermatogenesis in male akita type 1 diabetic mice. Endocrinology, 155(8), 2781-2786. https://doi.org/10.1210/en.2014-1119