TY - JOUR
T1 - Lentigo maligna melanoma of the head and neck
AU - Johns Langford, F. P.
AU - Fisher, Samuel R.
AU - Molter, David W.
AU - Seigler, Hilliard F.
PY - 1993/5
Y1 - 1993/5
N2 - Historically, lentigo maligna melanoma has been considered a “favorable” histological type of melanoma, and treatment by wide local excision was considered curative. A retrospective multivariate analysis of 143 head and neck patients with stage I lentigo maligna melanoma was performed from a database of 1067 head and neck patients followed at Duke Medical Center. Fifty-six percent of all lentigo maligna melanomas presented with lesions deeper than 0.76 mm, and 8% presented with stage II or III disease. Recurrent disease occurred in 45% of stage I patients, with a 5-year disease-free interval of 6 years and a median survival time of 10 years. Multivariate analysis demonstrated no significant difference in disease-free interval or survival by histological subtype. The data suggest that treatment should be based on tumor thickness and not histologic subtype.
AB - Historically, lentigo maligna melanoma has been considered a “favorable” histological type of melanoma, and treatment by wide local excision was considered curative. A retrospective multivariate analysis of 143 head and neck patients with stage I lentigo maligna melanoma was performed from a database of 1067 head and neck patients followed at Duke Medical Center. Fifty-six percent of all lentigo maligna melanomas presented with lesions deeper than 0.76 mm, and 8% presented with stage II or III disease. Recurrent disease occurred in 45% of stage I patients, with a 5-year disease-free interval of 6 years and a median survival time of 10 years. Multivariate analysis demonstrated no significant difference in disease-free interval or survival by histological subtype. The data suggest that treatment should be based on tumor thickness and not histologic subtype.
UR - http://www.scopus.com/inward/record.url?scp=0027299588&partnerID=8YFLogxK
U2 - 10.1288/00005537-199305000-00007
DO - 10.1288/00005537-199305000-00007
M3 - Article
C2 - 8483369
AN - SCOPUS:0027299588
SN - 0023-852X
VL - 103
SP - 520
EP - 524
JO - Laryngoscope
JF - Laryngoscope
IS - 5
ER -