Lensfree on-chip microscopy and tomography for biomedical applications

Serhan O. Isikman, Waheb Bishara, Onur Mudanyali, Ikbal Sencan, Ting Wei Su, Derek K. Tseng, Oguzhan Yaglidere, Uzair Sikora, Aydogan Ozcan

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Lensfree on-chip holographic microscopy is an emerging technique that offers imaging of biological specimens over a large field-of-view without using any lenses or bulky optical components. Lending itself to a compact, cost-effective, and mechanically robust architecture, lensfree on-chip holographic microscopy can offer an alternative toolset addressing some of the emerging needs of microscopic analysis and diagnostics in low-resource settings, especially for telemedicine applications. In this study, we summarize the latest achievements in lensfree optical microscopy based on partially coherent on-chip holography, including portable telemedicine microscopy, cell-phone-based microscopy, and field-portable optical tomographic microscopy. We also discuss some of the future directions for telemedicine microscopy and its prospects to help combat various global health challenges.

Original languageEnglish
Article number5944945
Pages (from-to)1059-1072
Number of pages14
JournalIEEE Journal on Selected Topics in Quantum Electronics
Issue number3
StatePublished - 2012


  • Cell-phone microscopy
  • global health
  • holographic pixel uper-resolution
  • lensfree imaging
  • lensfree tomography
  • lensless on-chip imaging
  • telemedicine microscopy


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