Lens ER-stress response during cataract development in Mip-mutant mice

Keyphrases

• Cataract 100%
• Mutant Mice 100%
• ER Stress Response 100%
• Major Intrinsic Proteins 66%
• DDIT3 66%
• CHAC1 66%
• Genetic Variants 33%
• Downregulated Genes 33%
• Endoplasmic Reticulum Stress (ER stress) 33%
• Quantitative PCR 33%
• Transcriptome Profiling 33%
• Lens Fiber Cell 33%
• Fiber Cells 33%
• Oxidative Stress 33%
• Age-related 33%
• Stress-induced 33%
• X-box Binding Protein 1 (XBP1) 33%
• Calpain 33%
• Hyperactivity 33%
• Microarray Hybridization 33%
• 4-fold 33%
• Pathogenic Mechanism 33%
• Free Radicals 33%
• Antioxidant 33%
• Induced Cell Death 33%
• Overproduction 33%
• Proteotoxic 33%
• Activating Transcription Factor 3 (ATF3) 33%
• Water Channel 33%
• Heme oxygenase-1 (HO-1) 33%
• Cell Architecture 33%
• Glutathione Depletion 33%
• Activating Transcription Factor 4 (ATF4) 33%
• TRIB3 33%
• Functional Fluid 33%
• Pathogenic Changes 33%
• HSPB1 33%
• AQP0 33%
• Terminal Deoxynucleotidyl Transferase dUTP Nick End Labeling (TUNEL) 33%

Biochemistry, Genetics and Molecular Biology

• Endoplasmic Reticulum Stress 100%
• Mouse Mutant 100%
• Major Intrinsic Proteins 100%
• Real-Time Polymerase Chain Reaction 50%
• Genetic Divergence 50%
• Gene Expression Profiling 50%
• Cell Death 50%
• Oxidative Stress 50%
• Calpain 50%
• Glutathione 50%
• Antioxidant Gene 50%